Anterior temporal lobe and the representation of knowledge about people
Patients with semantic dementia (SD), a neurodegenerative disease affecting the anterior temporal lobes (ATL) (1), present with striking cognitive deficits: they can have difficulties naming objects and familiar people from both pictures and descriptions (2, 3). Furthermore, SD patients make semanti...
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| Format: | Article |
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National Academy of Sciences
2017
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| Online Access: | http://hdl.handle.net/1721.1/112947 https://orcid.org/0000-0002-8964-6988 |
| _version_ | 1811085471758942208 |
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| author | Anzellotti, Stefano |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Anzellotti, Stefano |
| author_sort | Anzellotti, Stefano |
| collection | MIT |
| description | Patients with semantic dementia (SD), a neurodegenerative disease affecting the anterior temporal lobes (ATL) (1), present with striking cognitive deficits: they can have difficulties naming objects and familiar people from both pictures and descriptions (2, 3). Furthermore, SD patients make semantic errors (e.g., naming “horse” a picture of a zebra), suggesting that their impairment affects object knowledge rather than lexical retrieval. Because SD can affect object categories as disparate as artifacts, animals, and people, as well as multiple input modalities, it has been hypothesized that ATL is a semantic hub (4) that integrates information across multiple modality-specific brain regions into multimodal representations. With a series of converging experiments using multiple analysis techniques, Wang et al. (5) test the proposal that ATL is a semantic hub in the case of person knowledge, investigating whether ATL: (i) encodes multimodal representations of identity, and (ii) mediates the retrieval of knowledge about people from representations of perceptual cues. |
| first_indexed | 2024-09-23T13:10:07Z |
| format | Article |
| id | mit-1721.1/112947 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T13:10:07Z |
| publishDate | 2017 |
| publisher | National Academy of Sciences |
| record_format | dspace |
| spelling | mit-1721.1/1129472022-09-28T12:22:43Z Anterior temporal lobe and the representation of knowledge about people Anzellotti, Stefano Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Anzellotti, Stefano Patients with semantic dementia (SD), a neurodegenerative disease affecting the anterior temporal lobes (ATL) (1), present with striking cognitive deficits: they can have difficulties naming objects and familiar people from both pictures and descriptions (2, 3). Furthermore, SD patients make semantic errors (e.g., naming “horse” a picture of a zebra), suggesting that their impairment affects object knowledge rather than lexical retrieval. Because SD can affect object categories as disparate as artifacts, animals, and people, as well as multiple input modalities, it has been hypothesized that ATL is a semantic hub (4) that integrates information across multiple modality-specific brain regions into multimodal representations. With a series of converging experiments using multiple analysis techniques, Wang et al. (5) test the proposal that ATL is a semantic hub in the case of person knowledge, investigating whether ATL: (i) encodes multimodal representations of identity, and (ii) mediates the retrieval of knowledge about people from representations of perceptual cues. 2017-12-22T21:10:45Z 2017-12-22T21:10:45Z 2017-04 2017-12-22T17:09:08Z Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/112947 Anzellotti, Stefano. “Anterior Temporal Lobe and the Representation of Knowledge about People.” Proceedings of the National Academy of Sciences, vol. 114, no. 16, Apr. 2017, pp. 4042–44. © 2017 National Academy of Sciences https://orcid.org/0000-0002-8964-6988 http://dx.doi.org/10.1073/pnas.1703438114 Proceedings of the National Academy of Sciences Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences PNAS |
| spellingShingle | Anzellotti, Stefano Anterior temporal lobe and the representation of knowledge about people |
| title | Anterior temporal lobe and the representation of knowledge about people |
| title_full | Anterior temporal lobe and the representation of knowledge about people |
| title_fullStr | Anterior temporal lobe and the representation of knowledge about people |
| title_full_unstemmed | Anterior temporal lobe and the representation of knowledge about people |
| title_short | Anterior temporal lobe and the representation of knowledge about people |
| title_sort | anterior temporal lobe and the representation of knowledge about people |
| url | http://hdl.handle.net/1721.1/112947 https://orcid.org/0000-0002-8964-6988 |
| work_keys_str_mv | AT anzellottistefano anteriortemporallobeandtherepresentationofknowledgeaboutpeople |