Asymmetric Copper Hydride-Catalyzed Markovnikov Hydrosilylation of Vinylarenes and Vinyl Heterocycles
We report a highly enantioselective CuH-catalyzed Markovnikov hydrosilylation of vinylarenes and vinyl heterocycles. This method has a broad scope and enables both the synthesis of isolable silanes and the conversion of crude products to chiral alcohols. Density functional theory calculations suppor...
| Principais autores: | , , , , |
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| Outros Autores: | |
| Formato: | Artigo |
| Publicado em: |
American Chemical Society (ACS)
2018
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| Acesso em linha: | http://hdl.handle.net/1721.1/113039 https://orcid.org/0000-0003-2008-3264 https://orcid.org/0000-0002-7896-1683 https://orcid.org/0000-0001-5418-3082 https://orcid.org/0000-0003-3875-4775 |
| Resumo: | We report a highly enantioselective CuH-catalyzed Markovnikov hydrosilylation of vinylarenes and vinyl heterocycles. This method has a broad scope and enables both the synthesis of isolable silanes and the conversion of crude products to chiral alcohols. Density functional theory calculations support a mechanism proceeding by hydrocupration followed by σ-bond metathesis with a hydrosilane. |
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