Enantioselective Synthesis of Carbo- and Heterocycles through a CuH-Catalyzed Hydroalkylation Approach
The enantioselective, intramolecular hydroalkylation of halide-tethered styrenes has been achieved through a copper hydride-catalyzed process. This approach allowed for the synthesis of enantioenriched cyclobutanes, cyclopentanes, indanes, and six-membered N- and O-heterocycles. This protocol was ap...
Main Authors: | , , , , |
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Other Authors: | |
Format: | Article |
Published: |
American Chemical Society (ACS)
2018
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Online Access: | http://hdl.handle.net/1721.1/113059 https://orcid.org/0000-0001-6414-0908 https://orcid.org/0000-0003-3875-4775 |
Summary: | The enantioselective, intramolecular hydroalkylation of halide-tethered styrenes has been achieved through a copper hydride-catalyzed process. This approach allowed for the synthesis of enantioenriched cyclobutanes, cyclopentanes, indanes, and six-membered N- and O-heterocycles. This protocol was applied to the synthesis of the commercial serotonin reuptake inhibitor (-)-paroxetine. |
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