Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems
Adaptive immunity had been long thought of as an exclusive feature of animals. However, the discovery of the CRISPR-Cas defense system, present in almost half of prokaryotic genomes, proves otherwise. Because of the everlasting parasite-host arms race, CRISPR-Cas has rapidly evolved through horizont...
Main Authors: | Mohanraju, Prarthana, Makarova, Kira S., Koonin, Eugene V., van der Oost, John, Zetsche, Bernd, Zhang, Feng |
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Other Authors: | Broad Institute of MIT and Harvard |
Format: | Article |
Language: | en_US |
Published: |
American Association for the Advancement of Science (AAAS)
2018
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Online Access: | http://hdl.handle.net/1721.1/113195 https://orcid.org/0000-0003-2782-2509 |
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