Microfluidics: A New Tool for Modeling Cancer–Immune Interactions
In recognition of the enormous potential of immunotherapies against cancer, research into the interactions between tumor and immune cells has accelerated, leading to the recent FDA approval of several drugs that reduce cancer progression. Numerous cellular and molecular interactions have been identi...
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| Format: | Article |
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Elsevier
2018
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| Online Access: | http://hdl.handle.net/1721.1/113211 https://orcid.org/0000-0001-6316-5820 https://orcid.org/0000-0002-8537-8824 https://orcid.org/0000-0001-5418-5133 https://orcid.org/0000-0002-7232-304X |
| _version_ | 1826199647801049088 |
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| author | Wong, Siew Cheng Boussommier, Alexandra Li, Ran Chen, Michelle B Kamm, Roger Dale |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Wong, Siew Cheng Boussommier, Alexandra Li, Ran Chen, Michelle B Kamm, Roger Dale |
| author_sort | Wong, Siew Cheng |
| collection | MIT |
| description | In recognition of the enormous potential of immunotherapies against cancer, research into the interactions between tumor and immune cells has accelerated, leading to the recent FDA approval of several drugs that reduce cancer progression. Numerous cellular and molecular interactions have been identified by which immune cells can intervene in the metastatic cascade, leading to the development of several in vivo and in vitro model systems that can recapitulate these processes. Among these, microfluidic technologies hold many advantages in terms of their unique ability to capture the essential features of multiple cell type interactions in three-dimensions while allowing tight control of the microenvironment and real-time monitoring. Here, we review current assays and discuss the development of new microfluidic technologies for immunotherapy. Keywords
microfluidics
immunotherapy
metastatic cancer
drug screening |
| first_indexed | 2024-09-23T11:23:37Z |
| format | Article |
| id | mit-1721.1/113211 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T11:23:37Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1132112022-10-01T03:18:54Z Microfluidics: A New Tool for Modeling Cancer–Immune Interactions Wong, Siew Cheng Boussommier, Alexandra Li, Ran Chen, Michelle B Kamm, Roger Dale Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Mechanical Engineering Boussommier, Alexandra Li, Ran Chen, Michelle B Kamm, Roger Dale In recognition of the enormous potential of immunotherapies against cancer, research into the interactions between tumor and immune cells has accelerated, leading to the recent FDA approval of several drugs that reduce cancer progression. Numerous cellular and molecular interactions have been identified by which immune cells can intervene in the metastatic cascade, leading to the development of several in vivo and in vitro model systems that can recapitulate these processes. Among these, microfluidic technologies hold many advantages in terms of their unique ability to capture the essential features of multiple cell type interactions in three-dimensions while allowing tight control of the microenvironment and real-time monitoring. Here, we review current assays and discuss the development of new microfluidic technologies for immunotherapy. Keywords microfluidics immunotherapy metastatic cancer drug screening 2018-01-16T20:09:23Z 2018-01-16T20:09:23Z 2016-01 2018-01-16T18:48:04Z Article http://purl.org/eprint/type/JournalArticle 2405-8033 http://hdl.handle.net/1721.1/113211 Boussommier-Calleja, Alexandra et al. “Microfluidics: A New Tool for Modeling Cancer–Immune Interactions.” Trends in Cancer 2, 1 (January 2016): 6–19 © 2015 Elsevier Inc https://orcid.org/0000-0001-6316-5820 https://orcid.org/0000-0002-8537-8824 https://orcid.org/0000-0001-5418-5133 https://orcid.org/0000-0002-7232-304X http://dx.doi.org/10.1016/J.TRECAN.2015.12.003 Trends in Cancer Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Wong, Siew Cheng Boussommier, Alexandra Li, Ran Chen, Michelle B Kamm, Roger Dale Microfluidics: A New Tool for Modeling Cancer–Immune Interactions |
| title | Microfluidics: A New Tool for Modeling Cancer–Immune Interactions |
| title_full | Microfluidics: A New Tool for Modeling Cancer–Immune Interactions |
| title_fullStr | Microfluidics: A New Tool for Modeling Cancer–Immune Interactions |
| title_full_unstemmed | Microfluidics: A New Tool for Modeling Cancer–Immune Interactions |
| title_short | Microfluidics: A New Tool for Modeling Cancer–Immune Interactions |
| title_sort | microfluidics a new tool for modeling cancer immune interactions |
| url | http://hdl.handle.net/1721.1/113211 https://orcid.org/0000-0001-6316-5820 https://orcid.org/0000-0002-8537-8824 https://orcid.org/0000-0001-5418-5133 https://orcid.org/0000-0002-7232-304X |
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