Mouse Models of Gastric Cancer
Animal models have greatly enriched our understanding of the molecular mechanisms of numerous types of cancers. Gastric cancer is one of the most common cancers worldwide, with a poor prognosis and high incidence of drug-resistance. However, most inbred strains of mice have proven resistant to gastr...
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| Format: | Article |
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MDPI AG
2018
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| Online Access: | http://hdl.handle.net/1721.1/113333 |
| _version_ | 1811083693973831680 |
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| author | Hayakawa, Yoku Fox, James G. Gonda, Tamas Worthley, Daniel L. Wang, Timothy C. Fox, James Worthley, Daniel Wang, Timothy Muthupalani, Sureshkumar |
| author2 | Massachusetts Institute of Technology. Division of Comparative Medicine |
| author_facet | Massachusetts Institute of Technology. Division of Comparative Medicine Hayakawa, Yoku Fox, James G. Gonda, Tamas Worthley, Daniel L. Wang, Timothy C. Fox, James Worthley, Daniel Wang, Timothy Muthupalani, Sureshkumar |
| author_sort | Hayakawa, Yoku |
| collection | MIT |
| description | Animal models have greatly enriched our understanding of the molecular mechanisms of numerous types of cancers. Gastric cancer is one of the most common cancers worldwide, with a poor prognosis and high incidence of drug-resistance. However, most inbred strains of mice have proven resistant to gastric carcinogenesis. To establish useful models which mimic human gastric cancer phenotypes, investigators have utilized animals infected with <i>Helicobacter</i> species and treated with carcinogens. In addition, by exploiting genetic engineering, a variety of transgenic and knockout mouse models of gastric cancer have emerged, such as INS-GAS mice and TFF1 knockout mice. Investigators have used the combination of carcinogens and gene alteration to accelerate gastric cancer development, but rarely do mouse models show an aggressive and metastatic gastric cancer phenotype that could be relevant to preclinical studies, which may require more specific targeting of gastric progenitor cells. Here, we review current gastric carcinogenesis mouse models and provide our future perspectives on this field. Keywords: gastric cancer; mouse model; metaplasia; Helicobacter felis; Helicobacter pylori; INS-GAS mice |
| first_indexed | 2024-09-23T12:37:37Z |
| format | Article |
| id | mit-1721.1/113333 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T12:37:37Z |
| publishDate | 2018 |
| publisher | MDPI AG |
| record_format | dspace |
| spelling | mit-1721.1/1133332022-09-28T09:05:14Z Mouse Models of Gastric Cancer Hayakawa, Yoku Fox, James G. Gonda, Tamas Worthley, Daniel L. Wang, Timothy C. Fox, James Worthley, Daniel Wang, Timothy Muthupalani, Sureshkumar Massachusetts Institute of Technology. Division of Comparative Medicine Muthupalani, Sureshkumar Animal models have greatly enriched our understanding of the molecular mechanisms of numerous types of cancers. Gastric cancer is one of the most common cancers worldwide, with a poor prognosis and high incidence of drug-resistance. However, most inbred strains of mice have proven resistant to gastric carcinogenesis. To establish useful models which mimic human gastric cancer phenotypes, investigators have utilized animals infected with <i>Helicobacter</i> species and treated with carcinogens. In addition, by exploiting genetic engineering, a variety of transgenic and knockout mouse models of gastric cancer have emerged, such as INS-GAS mice and TFF1 knockout mice. Investigators have used the combination of carcinogens and gene alteration to accelerate gastric cancer development, but rarely do mouse models show an aggressive and metastatic gastric cancer phenotype that could be relevant to preclinical studies, which may require more specific targeting of gastric progenitor cells. Here, we review current gastric carcinogenesis mouse models and provide our future perspectives on this field. Keywords: gastric cancer; mouse model; metaplasia; Helicobacter felis; Helicobacter pylori; INS-GAS mice 2018-01-29T19:18:24Z 2018-01-29T19:18:24Z 2013-01 2013-01 2018-01-24T21:04:37Z Article http://purl.org/eprint/type/JournalArticle 2072-6694 http://hdl.handle.net/1721.1/113333 Hayakawa, Yoku et al. "Mouse Models of Gastric Cancer." Cancers 5, 1(January 2013): 92-130 © 2013 The Author(s) http://dx.doi.org/10.3390/cancers5010092 Cancers Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf MDPI AG Multidisciplinary Digital Publishing Institute |
| spellingShingle | Hayakawa, Yoku Fox, James G. Gonda, Tamas Worthley, Daniel L. Wang, Timothy C. Fox, James Worthley, Daniel Wang, Timothy Muthupalani, Sureshkumar Mouse Models of Gastric Cancer |
| title | Mouse Models of Gastric Cancer |
| title_full | Mouse Models of Gastric Cancer |
| title_fullStr | Mouse Models of Gastric Cancer |
| title_full_unstemmed | Mouse Models of Gastric Cancer |
| title_short | Mouse Models of Gastric Cancer |
| title_sort | mouse models of gastric cancer |
| url | http://hdl.handle.net/1721.1/113333 |
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