Nanofibrous Silver-Coated Polymeric Scaffolds with Tunable Electrical Properties
Electrospun micro- and nanofibrous poly(glycerol sebacate)-poly(ε-caprolactone) (PGS-PCL) substrates have been extensively used as scaffolds for engineered tissues due to their desirable mechanical properties and their tunable degradability. In this study, we fabricated micro/nanofibrous scaffolds f...
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| Format: | Article |
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MDPI AG
2018
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| Online Access: | http://hdl.handle.net/1721.1/113336 |
| _version_ | 1811092302082342912 |
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| author | Memic, Adnan Aldhahri, Musab Tamayol, Ali Mostafalu, Pooria Abdel-wahab, Mohamed Shaaban Samandari, Mohamadmahdi Moghaddam, Kamyar Mollazadeh Annabi, Nasim Bencherif, Sidi A. Khademhosseini, Ali Abdel-wahab, Mohamed Moghaddam, Kamyar Bencherif, Sidi Khademhosseini, Alireza |
| author2 | Institute for Medical Engineering and Science |
| author_facet | Institute for Medical Engineering and Science Memic, Adnan Aldhahri, Musab Tamayol, Ali Mostafalu, Pooria Abdel-wahab, Mohamed Shaaban Samandari, Mohamadmahdi Moghaddam, Kamyar Mollazadeh Annabi, Nasim Bencherif, Sidi A. Khademhosseini, Ali Abdel-wahab, Mohamed Moghaddam, Kamyar Bencherif, Sidi Khademhosseini, Alireza |
| author_sort | Memic, Adnan |
| collection | MIT |
| description | Electrospun micro- and nanofibrous poly(glycerol sebacate)-poly(ε-caprolactone) (PGS-PCL) substrates have been extensively used as scaffolds for engineered tissues due to their desirable mechanical properties and their tunable degradability. In this study, we fabricated micro/nanofibrous scaffolds from a PGS-PCL composite using a standard electrospinning approach and then coated them with silver (Ag) using a custom radio frequency (RF) sputtering method. The Ag coating formed an electrically conductive layer around the fibers and decreased the pore size. The thickness of the Ag coating could be controlled, thereby tailoring the conductivity of the substrate. The flexible, stretchable patches formed excellent conformal contact with surrounding tissues and possessed excellent pattern-substrate fidelity. In vitro studies confirmed the platform’s biocompatibility and biodegradability. Finally, the potential controlled release of the Ag coating from the composite fibrous scaffolds could be beneficial for many clinical applications. Keywords: electrospinning; electrical properties; nanocoatings; flexible electronics |
| first_indexed | 2024-09-23T15:15:53Z |
| format | Article |
| id | mit-1721.1/113336 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T15:15:53Z |
| publishDate | 2018 |
| publisher | MDPI AG |
| record_format | dspace |
| spelling | mit-1721.1/1133362022-09-29T13:47:05Z Nanofibrous Silver-Coated Polymeric Scaffolds with Tunable Electrical Properties Memic, Adnan Aldhahri, Musab Tamayol, Ali Mostafalu, Pooria Abdel-wahab, Mohamed Shaaban Samandari, Mohamadmahdi Moghaddam, Kamyar Mollazadeh Annabi, Nasim Bencherif, Sidi A. Khademhosseini, Ali Abdel-wahab, Mohamed Moghaddam, Kamyar Bencherif, Sidi Khademhosseini, Alireza Institute for Medical Engineering and Science Harvard University--MIT Division of Health Sciences and Technology Khademhosseini, Alireza Electrospun micro- and nanofibrous poly(glycerol sebacate)-poly(ε-caprolactone) (PGS-PCL) substrates have been extensively used as scaffolds for engineered tissues due to their desirable mechanical properties and their tunable degradability. In this study, we fabricated micro/nanofibrous scaffolds from a PGS-PCL composite using a standard electrospinning approach and then coated them with silver (Ag) using a custom radio frequency (RF) sputtering method. The Ag coating formed an electrically conductive layer around the fibers and decreased the pore size. The thickness of the Ag coating could be controlled, thereby tailoring the conductivity of the substrate. The flexible, stretchable patches formed excellent conformal contact with surrounding tissues and possessed excellent pattern-substrate fidelity. In vitro studies confirmed the platform’s biocompatibility and biodegradability. Finally, the potential controlled release of the Ag coating from the composite fibrous scaffolds could be beneficial for many clinical applications. Keywords: electrospinning; electrical properties; nanocoatings; flexible electronics 2018-01-29T19:43:34Z 2018-01-29T19:43:34Z 2017-03 2017-01 2018-01-24T21:05:07Z Article http://purl.org/eprint/type/JournalArticle 2079-4991 http://hdl.handle.net/1721.1/113336 Memic, Adnan et al. "Nanofibrous Silver-Coated Polymeric Scaffolds with Tunable Electrical Properties." Nanomaterials 7, 3 (2017 March): 63 © 2017 The Author(s) http://dx.doi.org/10.3390/nano7030063 Nanomaterials Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf MDPI AG Multidisciplinary Digital Publishing Institute |
| spellingShingle | Memic, Adnan Aldhahri, Musab Tamayol, Ali Mostafalu, Pooria Abdel-wahab, Mohamed Shaaban Samandari, Mohamadmahdi Moghaddam, Kamyar Mollazadeh Annabi, Nasim Bencherif, Sidi A. Khademhosseini, Ali Abdel-wahab, Mohamed Moghaddam, Kamyar Bencherif, Sidi Khademhosseini, Alireza Nanofibrous Silver-Coated Polymeric Scaffolds with Tunable Electrical Properties |
| title | Nanofibrous Silver-Coated Polymeric Scaffolds with Tunable Electrical Properties |
| title_full | Nanofibrous Silver-Coated Polymeric Scaffolds with Tunable Electrical Properties |
| title_fullStr | Nanofibrous Silver-Coated Polymeric Scaffolds with Tunable Electrical Properties |
| title_full_unstemmed | Nanofibrous Silver-Coated Polymeric Scaffolds with Tunable Electrical Properties |
| title_short | Nanofibrous Silver-Coated Polymeric Scaffolds with Tunable Electrical Properties |
| title_sort | nanofibrous silver coated polymeric scaffolds with tunable electrical properties |
| url | http://hdl.handle.net/1721.1/113336 |
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