Micro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactions
As our population ages, there is a greater need for a suitable supply of engineered tissues to address a range of debilitating ailments. Stem cell based therapies are envisioned to meet this emerging need. Despite significant progress in controlling stem cell differentiation, it is still difficult t...
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| Format: | Article |
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MDPI AG
2018
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| Online Access: | http://hdl.handle.net/1721.1/113375 |
| _version_ | 1826204606073405440 |
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| author | Dolatshahi-Pirouz, Alireza Nikkhah, Mehdi Kolind, Kristian Dokmeci, Mehmet R. Khademhosseini, Alireza |
| author2 | Institute for Medical Engineering and Science |
| author_facet | Institute for Medical Engineering and Science Dolatshahi-Pirouz, Alireza Nikkhah, Mehdi Kolind, Kristian Dokmeci, Mehmet R. Khademhosseini, Alireza |
| author_sort | Dolatshahi-Pirouz, Alireza |
| collection | MIT |
| description | As our population ages, there is a greater need for a suitable supply of engineered tissues to address a range of debilitating ailments. Stem cell based therapies are envisioned to meet this emerging need. Despite significant progress in controlling stem cell differentiation, it is still difficult to engineer human tissue constructs for transplantation. Recent advances in micro- and nanofabrication techniques have enabled the design of more biomimetic biomaterials that may be used to direct the fate of stem cells. These biomaterials could have a significant impact on the next generation of stem cell based therapies. Here, we highlight the recent progress made by micro- and nanoengineering techniques in the biomaterials field in the context of directing stem cell differentiation. Particular attention is given to the effect of surface topography, chemistry, mechanics and micro- and nanopatterns on the differentiation of embryonic, mesenchymal and neural stem cells. Keywords: micro- and nanotopography; microwells; microarrays; embryonic and adult stem cells; stem cell therapy |
| first_indexed | 2024-09-23T12:58:07Z |
| format | Article |
| id | mit-1721.1/113375 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T12:58:07Z |
| publishDate | 2018 |
| publisher | MDPI AG |
| record_format | dspace |
| spelling | mit-1721.1/1133752022-09-28T11:13:39Z Micro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactions Dolatshahi-Pirouz, Alireza Nikkhah, Mehdi Kolind, Kristian Dokmeci, Mehmet R. Khademhosseini, Alireza Institute for Medical Engineering and Science Harvard University--MIT Division of Health Sciences and Technology Khademhosseini, Alireza As our population ages, there is a greater need for a suitable supply of engineered tissues to address a range of debilitating ailments. Stem cell based therapies are envisioned to meet this emerging need. Despite significant progress in controlling stem cell differentiation, it is still difficult to engineer human tissue constructs for transplantation. Recent advances in micro- and nanofabrication techniques have enabled the design of more biomimetic biomaterials that may be used to direct the fate of stem cells. These biomaterials could have a significant impact on the next generation of stem cell based therapies. Here, we highlight the recent progress made by micro- and nanoengineering techniques in the biomaterials field in the context of directing stem cell differentiation. Particular attention is given to the effect of surface topography, chemistry, mechanics and micro- and nanopatterns on the differentiation of embryonic, mesenchymal and neural stem cells. Keywords: micro- and nanotopography; microwells; microarrays; embryonic and adult stem cells; stem cell therapy National Institutes of Health (U.S.) (Grant HL092836) National Institutes of Health (U.S.) (Grant DE019024) National Institutes of Health (U.S.) (Grant EB008392) National Institutes of Health (U.S.) (Grant DE021468) National Institutes of Health (U.S.) (Grant AR05837) National Institutes of Health (U.S.) (Grant EB012597) National Institutes of Health (U.S.) (Grant HL099073) National Science Foundation (U.S.) (Award DMR 0847287) 2018-01-31T14:10:10Z 2018-01-31T14:10:10Z 2011-06 2011-06 2018-01-24T21:03:27Z Article http://purl.org/eprint/type/JournalArticle 2079-4983 http://hdl.handle.net/1721.1/113375 Dolatshahi-Pirouz, Alireza et al. "Micro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactions." Journal of Functional Biomaterials 2, 3 (June 2011): 88-106 © 2011 The Author(s) http://dx.doi.org/10.3390/jfb2030088 Journal of Functional Biomaterials Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf MDPI AG Multidisciplinary Digital Publishing Institute |
| spellingShingle | Dolatshahi-Pirouz, Alireza Nikkhah, Mehdi Kolind, Kristian Dokmeci, Mehmet R. Khademhosseini, Alireza Micro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactions |
| title | Micro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactions |
| title_full | Micro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactions |
| title_fullStr | Micro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactions |
| title_full_unstemmed | Micro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactions |
| title_short | Micro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactions |
| title_sort | micro and nanoengineering approaches to control stem cell biomaterial interactions |
| url | http://hdl.handle.net/1721.1/113375 |
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