Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

Tissue architecture contributes to pancreatic ductal adenocarcinoma (PDAC) phenotypes. Cancer cells within PDAC form gland-like structures embedded in a collagen-rich meshwork where nutrients and oxygen are scarce. Altered metabolism is needed for tumour cells to survive in this environment, but the...

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Bibliographic Details
Main Authors:	Olivares, Orianne, Mayers, Jared R., Gouirand, Victoire, Torrence, Margaret E., Gicquel, Tristan, Borge, Laurence, Lac, Sophie, Roques, Julie, Lavaut, Marie-Noëlle, Berthezène, Patrice, Rubis, Marion, Secq, Veronique, Garcia, Stéphane, Moutardier, Vincent, Lombardo, Dominique, Iovanna, Juan Lucio, Tomasini, Richard, Guillaumond, Fabienne, Vander Heiden, Matthew G., Vasseur, Sophie
Other Authors:	Massachusetts Institute of Technology. Department of Biology
Format:	Article
Published:	Nature Publishing Group 2018
Online Access:	http://hdl.handle.net/1721.1/113569 https://orcid.org/0000-0002-8607-1787 https://orcid.org/0000-0002-6702-4192

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