Irregular sleep/wake patterns are associated with poorer academic performance and delayed circadian and sleep/wake timing
The association of irregular sleep schedules with circadian timing and academic performance has not been systematically examined. We studied 61 undergraduates for 30 days using sleep diaries, and quantified sleep regularity using a novel metric, the sleep regularity index (SRI). In the most and leas...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
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Springer Nature
2018
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| Online Access: | http://hdl.handle.net/1721.1/113615 https://orcid.org/0000-0002-5661-0022 https://orcid.org/0000-0003-4484-8946 |
| _version_ | 1811087400704671744 |
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| author | Phillips, Andrew J. K. Clerx, William M. O’Brien, Conor S. Sano, Akane Barger, Laura K. Picard, Rosalind W. Lockley, Steven W. Klerman, Elizabeth B. Czeisler, Charles A. |
| author2 | Massachusetts Institute of Technology. Media Laboratory |
| author_facet | Massachusetts Institute of Technology. Media Laboratory Phillips, Andrew J. K. Clerx, William M. O’Brien, Conor S. Sano, Akane Barger, Laura K. Picard, Rosalind W. Lockley, Steven W. Klerman, Elizabeth B. Czeisler, Charles A. |
| author_sort | Phillips, Andrew J. K. |
| collection | MIT |
| description | The association of irregular sleep schedules with circadian timing and academic performance has not been systematically examined. We studied 61 undergraduates for 30 days using sleep diaries, and quantified sleep regularity using a novel metric, the sleep regularity index (SRI). In the most and least regular quintiles, circadian phase and light exposure were assessed using salivary dim-light melatonin onset (DLMO) and wrist-worn photometry, respectively. DLMO occurred later (00:08 ± 1:54 vs. 21:32 ± 1:48; p < 0.003); the daily sleep propensity rhythm peaked later (06:33 ± 0:19 vs. 04:45 ± 0:11; p < 0.005); and light rhythms had lower amplitude (102 ± 19 lux vs. 179 ± 29 lux; p < 0.005) in Irregular compared to Regular sleepers. A mathematical model of the circadian pacemaker and its response to light was used to demonstrate that Irregular vs. Regular group differences in circadian timing were likely primarily due to their different patterns of light exposure. A positive correlation (r = 0.37; p < 0.004) between academic performance and SRI was observed. These findings show that irregular sleep and light exposure patterns in college students are associated with delayed circadian rhythms and lower academic performance. Moreover, the modeling results reveal that light-based interventions may be therapeutically effective in improving sleep regularity in this population. |
| first_indexed | 2024-09-23T13:45:30Z |
| format | Article |
| id | mit-1721.1/113615 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T13:45:30Z |
| publishDate | 2018 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | mit-1721.1/1136152022-10-01T16:57:35Z Irregular sleep/wake patterns are associated with poorer academic performance and delayed circadian and sleep/wake timing Phillips, Andrew J. K. Clerx, William M. O’Brien, Conor S. Sano, Akane Barger, Laura K. Picard, Rosalind W. Lockley, Steven W. Klerman, Elizabeth B. Czeisler, Charles A. Massachusetts Institute of Technology. Media Laboratory Program in Media Arts and Sciences (Massachusetts Institute of Technology) Picard, Rosalind W. Sano, Akane The association of irregular sleep schedules with circadian timing and academic performance has not been systematically examined. We studied 61 undergraduates for 30 days using sleep diaries, and quantified sleep regularity using a novel metric, the sleep regularity index (SRI). In the most and least regular quintiles, circadian phase and light exposure were assessed using salivary dim-light melatonin onset (DLMO) and wrist-worn photometry, respectively. DLMO occurred later (00:08 ± 1:54 vs. 21:32 ± 1:48; p < 0.003); the daily sleep propensity rhythm peaked later (06:33 ± 0:19 vs. 04:45 ± 0:11; p < 0.005); and light rhythms had lower amplitude (102 ± 19 lux vs. 179 ± 29 lux; p < 0.005) in Irregular compared to Regular sleepers. A mathematical model of the circadian pacemaker and its response to light was used to demonstrate that Irregular vs. Regular group differences in circadian timing were likely primarily due to their different patterns of light exposure. A positive correlation (r = 0.37; p < 0.004) between academic performance and SRI was observed. These findings show that irregular sleep and light exposure patterns in college students are associated with delayed circadian rhythms and lower academic performance. Moreover, the modeling results reveal that light-based interventions may be therapeutically effective in improving sleep regularity in this population. National Institutes of Health (U.S.) (R01-GM-105018) National Institutes of Health (U.S.) (R01-HL-114088) National Institutes of Health (U.S.) (R01-HL094654) National Institutes of Health (U.S.) (P01-AG09975) National Institutes of Health (U.S.) (K24-HL105664) National Institutes of Health (U.S.) (K99-HL119618) National Institutes of Health (U.S.) (R00-HL119618) National Space Biomedical Research Institute (HFP0280) National Space Biomedical Research Institute (HFP02802) National Space Biomedical Research Institute (HFP02801) 2018-02-12T23:29:17Z 2018-02-12T23:29:17Z 2017-06 2016-12 2018-02-09T17:00:36Z Article http://purl.org/eprint/type/JournalArticle 2045-2322 http://hdl.handle.net/1721.1/113615 Phillips, Andrew J. K., William M. Clerx, Conor S. O’Brien, Akane Sano, Laura K. Barger, Rosalind W. Picard, Steven W. Lockley, Elizabeth B. Klerman, and Charles A. Czeisler. “Irregular Sleep/wake Patterns Are Associated with Poorer Academic Performance and Delayed Circadian and Sleep/wake Timing.” Scientific Reports 7, no. 1 (June 12, 2017). https://orcid.org/0000-0002-5661-0022 https://orcid.org/0000-0003-4484-8946 http://dx.doi.org/10.1038/S41598-017-03171-4 Scientific Reports Creative Commons Attribution 4.0 International License https://creativecommons.org/licenses/by/4.0/ application/pdf Springer Nature |
| spellingShingle | Phillips, Andrew J. K. Clerx, William M. O’Brien, Conor S. Sano, Akane Barger, Laura K. Picard, Rosalind W. Lockley, Steven W. Klerman, Elizabeth B. Czeisler, Charles A. Irregular sleep/wake patterns are associated with poorer academic performance and delayed circadian and sleep/wake timing |
| title | Irregular sleep/wake patterns are associated with poorer academic performance and delayed circadian and sleep/wake timing |
| title_full | Irregular sleep/wake patterns are associated with poorer academic performance and delayed circadian and sleep/wake timing |
| title_fullStr | Irregular sleep/wake patterns are associated with poorer academic performance and delayed circadian and sleep/wake timing |
| title_full_unstemmed | Irregular sleep/wake patterns are associated with poorer academic performance and delayed circadian and sleep/wake timing |
| title_short | Irregular sleep/wake patterns are associated with poorer academic performance and delayed circadian and sleep/wake timing |
| title_sort | irregular sleep wake patterns are associated with poorer academic performance and delayed circadian and sleep wake timing |
| url | http://hdl.handle.net/1721.1/113615 https://orcid.org/0000-0002-5661-0022 https://orcid.org/0000-0003-4484-8946 |
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