Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer

Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer

Advanced-stage epithelial ovarian cancers are amongst the most difficult to treat tumors and have proven to be refractory to most cytotoxic, molecularly targeted, or immunotherapeutic approaches. Here, we report that nanoparticle-drug conjugates (NDCs) of monomethyl auristatin E (MMAE) significantly...

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Bibliographic Details
Main Authors: Lauffer, Sam, Matulonis, Ursula, Pepin, David, Birrer, Michael J., Qi, Ruogu, Wang, Yongheng, Bruno, Peter Michael, Xiao, Haihua, Yu, Yingjie, Li, Ting, Chen, Qixian, Kang, Xiang, Song, Haiqin, Yang, Xi, Huang, Xing, Detappe, Alexandre, Hemann, Michael, Ghoroghchian, Paiman Peter, Wei, Wei, S.M. Massachusetts Institute of Technology. Department of Civil and Environmental Engineering
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Published: Nature Publishing Group 2018
Online Access:http://hdl.handle.net/1721.1/113634
https://orcid.org/0000-0001-5088-5810
https://orcid.org/0000-0003-3383-0118
https://orcid.org/0000-0002-2515-5602

Internet

http://hdl.handle.net/1721.1/113634
https://orcid.org/0000-0001-5088-5810
https://orcid.org/0000-0003-3383-0118
https://orcid.org/0000-0002-2515-5602

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