Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers
Aggregation of amphiphiles through the action of hydrophobic interactions is a common feature in soft condensed matter systems and is of particular importance in the context of biophysics as it underlies both the generation of functional biological machinery as well as the formation of pathological...
| Main Authors: | , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Published: |
American Institute of Physics (AIP)
2018
|
| Online Access: | http://hdl.handle.net/1721.1/113639 |
| _version_ | 1826195344074997760 |
|---|---|
| author | Varilly, Patrick Willard, Adam P. Kirkegaard, Julius B. Knowles, Tuomas P. J. Chandler, David |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Varilly, Patrick Willard, Adam P. Kirkegaard, Julius B. Knowles, Tuomas P. J. Chandler, David |
| author_sort | Varilly, Patrick |
| collection | MIT |
| description | Aggregation of amphiphiles through the action of hydrophobic interactions is a common feature in soft condensed matter systems and is of particular importance in the context of biophysics as it underlies both the generation of functional biological machinery as well as the formation of pathological misassembled states of proteins. Here we explore the aggregation behaviour of amphiphilic polymers using lattice Monte Carlo calculations and show that the distribution of hydrophobic residues within the polymer sequence determines the facility with which dry/wet interfaces can be created and that such interfaces drive the aggregation process. |
| first_indexed | 2024-09-23T10:11:11Z |
| format | Article |
| id | mit-1721.1/113639 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T10:11:11Z |
| publishDate | 2018 |
| publisher | American Institute of Physics (AIP) |
| record_format | dspace |
| spelling | mit-1721.1/1136392022-09-26T16:18:08Z Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers Varilly, Patrick Willard, Adam P. Kirkegaard, Julius B. Knowles, Tuomas P. J. Chandler, David Massachusetts Institute of Technology. Department of Chemistry Willard, Adam P. Aggregation of amphiphiles through the action of hydrophobic interactions is a common feature in soft condensed matter systems and is of particular importance in the context of biophysics as it underlies both the generation of functional biological machinery as well as the formation of pathological misassembled states of proteins. Here we explore the aggregation behaviour of amphiphilic polymers using lattice Monte Carlo calculations and show that the distribution of hydrophobic residues within the polymer sequence determines the facility with which dry/wet interfaces can be created and that such interfaces drive the aggregation process. 2018-02-13T20:27:06Z 2018-02-13T20:27:06Z 2017-04 2016-10 2018-02-09T15:30:24Z Article http://purl.org/eprint/type/JournalArticle 0021-9606 1089-7690 http://hdl.handle.net/1721.1/113639 Varilly, Patrick et al. “Intra-Chain Organisation of Hydrophobic Residues Controls Inter-Chain Aggregation Rates of Amphiphilic Polymers.” The Journal of Chemical Physics 146, 13 (April 2017): 135102 © 2017 Author(s) http://dx.doi.org/10.1063/1.4977932 The Journal of Chemical Physics Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Institute of Physics (AIP) arXiv |
| spellingShingle | Varilly, Patrick Willard, Adam P. Kirkegaard, Julius B. Knowles, Tuomas P. J. Chandler, David Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers |
| title | Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers |
| title_full | Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers |
| title_fullStr | Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers |
| title_full_unstemmed | Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers |
| title_short | Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers |
| title_sort | intra chain organisation of hydrophobic residues controls inter chain aggregation rates of amphiphilic polymers |
| url | http://hdl.handle.net/1721.1/113639 |
| work_keys_str_mv | AT varillypatrick intrachainorganisationofhydrophobicresiduescontrolsinterchainaggregationratesofamphiphilicpolymers AT willardadamp intrachainorganisationofhydrophobicresiduescontrolsinterchainaggregationratesofamphiphilicpolymers AT kirkegaardjuliusb intrachainorganisationofhydrophobicresiduescontrolsinterchainaggregationratesofamphiphilicpolymers AT knowlestuomaspj intrachainorganisationofhydrophobicresiduescontrolsinterchainaggregationratesofamphiphilicpolymers AT chandlerdavid intrachainorganisationofhydrophobicresiduescontrolsinterchainaggregationratesofamphiphilicpolymers |