Tumor-Associated Tertiary Lymphoid Structures: Gene-Expression Profiling and Their Bioengineering
Tertiary lymphoid structures (TLSs) have been identified in the parenchyma and/or in the peripheral margins of human solid tumors. Uncovering the functional nature of these structures is the subject of much intensive investigation. Studies have shown a direct correlation of the presence of human tum...
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Frontiers Research Foundation
2018
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| Online Access: | http://hdl.handle.net/1721.1/114036 |
| _version_ | 1826215636559200256 |
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| author | Zhu, Genyuan Falahat, Rana Wang, Kui Mailloux, Adam Artzi, Natalie Mulé, James J. |
| author2 | Institute for Medical Engineering and Science |
| author_facet | Institute for Medical Engineering and Science Zhu, Genyuan Falahat, Rana Wang, Kui Mailloux, Adam Artzi, Natalie Mulé, James J. |
| author_sort | Zhu, Genyuan |
| collection | MIT |
| description | Tertiary lymphoid structures (TLSs) have been identified in the parenchyma and/or in the peripheral margins of human solid tumors. Uncovering the functional nature of these structures is the subject of much intensive investigation. Studies have shown a direct correlation of the presence of human tumor-localized TLS and better patient outcome (e.g., increase in overall survival) in certain solid tumor histologies, but not all. We had identified a tumor-derived immune gene-expression signature, encoding 12 distinct chemokines, which could reliably identify the presence of TLSs, of different degrees, in various human solid tumors. We are focused on understanding the influence of TLSs on the tumor microenvironment and leveraging this understanding to both manipulate the antitumor immune response and potentially enhance immunotherapy applications. Moreover, as not all human solid tumors show the presence of these lymphoid structures, we are embarking on bioengineering approaches to design and build "designer" TLSs to address, and potentially overcome, an unmet medical need in cancer patients whose tumors lack such lymphoid structures. |
| first_indexed | 2024-09-23T16:37:04Z |
| format | Article |
| id | mit-1721.1/114036 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T16:37:04Z |
| publishDate | 2018 |
| publisher | Frontiers Research Foundation |
| record_format | dspace |
| spelling | mit-1721.1/1140362022-10-02T08:28:17Z Tumor-Associated Tertiary Lymphoid Structures: Gene-Expression Profiling and Their Bioengineering Zhu, Genyuan Falahat, Rana Wang, Kui Mailloux, Adam Artzi, Natalie Mulé, James J. Institute for Medical Engineering and Science Wang, Kui Artzi, Natalie Tertiary lymphoid structures (TLSs) have been identified in the parenchyma and/or in the peripheral margins of human solid tumors. Uncovering the functional nature of these structures is the subject of much intensive investigation. Studies have shown a direct correlation of the presence of human tumor-localized TLS and better patient outcome (e.g., increase in overall survival) in certain solid tumor histologies, but not all. We had identified a tumor-derived immune gene-expression signature, encoding 12 distinct chemokines, which could reliably identify the presence of TLSs, of different degrees, in various human solid tumors. We are focused on understanding the influence of TLSs on the tumor microenvironment and leveraging this understanding to both manipulate the antitumor immune response and potentially enhance immunotherapy applications. Moreover, as not all human solid tumors show the presence of these lymphoid structures, we are embarking on bioengineering approaches to design and build "designer" TLSs to address, and potentially overcome, an unmet medical need in cancer patients whose tumors lack such lymphoid structures. National Cancer Institute (U.S.) (Award 1R01 CA148995) National Cancer Institute (U.S.) (Award 1R01 CA184845) National Cancer Institute (U.S.) (Award P30 CA076292) National Cancer Institute (U.S.) (Award P50 CA168536) 2018-03-06T23:12:52Z 2018-03-06T23:12:52Z 2017-06 2017-03 2018-02-16T19:28:22Z Article http://purl.org/eprint/type/JournalArticle 1664-3224 http://hdl.handle.net/1721.1/114036 Zhu, Genyuan, Rana Falahat, Kui Wang, Adam Mailloux, Natalie Artzi, and James J. Mulé. “Tumor-Associated Tertiary Lymphoid Structures: Gene-Expression Profiling and Their Bioengineering.” Frontiers in Immunology 8 (June 2017): 767 © 2017 The Authors http://dx.doi.org/10.3389/fimmu.2017.00767 Frontiers in Immunology Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/ application/pdf Frontiers Research Foundation Frontiers |
| spellingShingle | Zhu, Genyuan Falahat, Rana Wang, Kui Mailloux, Adam Artzi, Natalie Mulé, James J. Tumor-Associated Tertiary Lymphoid Structures: Gene-Expression Profiling and Their Bioengineering |
| title | Tumor-Associated Tertiary Lymphoid Structures: Gene-Expression Profiling and Their Bioengineering |
| title_full | Tumor-Associated Tertiary Lymphoid Structures: Gene-Expression Profiling and Their Bioengineering |
| title_fullStr | Tumor-Associated Tertiary Lymphoid Structures: Gene-Expression Profiling and Their Bioengineering |
| title_full_unstemmed | Tumor-Associated Tertiary Lymphoid Structures: Gene-Expression Profiling and Their Bioengineering |
| title_short | Tumor-Associated Tertiary Lymphoid Structures: Gene-Expression Profiling and Their Bioengineering |
| title_sort | tumor associated tertiary lymphoid structures gene expression profiling and their bioengineering |
| url | http://hdl.handle.net/1721.1/114036 |
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