The amygdala in value-guided decision making
Thesis: Ph. D. in Neuroscience, Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, 2017.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2018
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| Online Access: | http://hdl.handle.net/1721.1/114076 |
| _version_ | 1826207292065841152 |
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| author | Jaime-Bustamante, Kean (Kean Willyams) |
| author2 | Susumu Tonegawa. |
| author_facet | Susumu Tonegawa. Jaime-Bustamante, Kean (Kean Willyams) |
| author_sort | Jaime-Bustamante, Kean (Kean Willyams) |
| collection | MIT |
| description | Thesis: Ph. D. in Neuroscience, Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, 2017. |
| first_indexed | 2024-09-23T13:47:03Z |
| format | Thesis |
| id | mit-1721.1/114076 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T13:47:03Z |
| publishDate | 2018 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/1140762019-04-10T19:05:25Z The amygdala in value-guided decision making Jaime-Bustamante, Kean (Kean Willyams) Susumu Tonegawa. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences. Brain and Cognitive Sciences. Thesis: Ph. D. in Neuroscience, Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, 2017. Cataloged from PDF version of thesis. Includes bibliographical references. The amygdala is a structure well known for its role in fear and reward learning, but how these mechanisms are used for decision-making is not well understood. Decision-making involves the rapid updating of cue associations as well as the encoding of a value currency, both processes in which the amygdala has been implicated. In this thesis I develop a strategy to study value-guided decision making in rodents using an olfactory binary choice task. Using a logistic regression model, I show that the value of expected rewards is a strong influence on choice, and can bias perceptual decisions. In addition, I show that decisions are influenced by events in the near past, and a specific bias towards correct choices in the near past can be detected using this analysis. Using genetic targeting of a sub-population of amygdala neurons, I show that this population is required for the rapid learning of an olfactory decision making task. Using in-vivo calcium imaging of this population I show that these neurons are active during the inter-trial interval and modulated by choice history, suggesting a mechanism by which choice history can influence current decisions. by Kean Jaime-Bustamante. Ph. D. in Neuroscience 2018-03-12T19:28:52Z 2018-03-12T19:28:52Z 2017 2017 Thesis http://hdl.handle.net/1721.1/114076 1027213794 eng MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. http://dspace.mit.edu/handle/1721.1/7582 122 pages application/pdf Massachusetts Institute of Technology |
| spellingShingle | Brain and Cognitive Sciences. Jaime-Bustamante, Kean (Kean Willyams) The amygdala in value-guided decision making |
| title | The amygdala in value-guided decision making |
| title_full | The amygdala in value-guided decision making |
| title_fullStr | The amygdala in value-guided decision making |
| title_full_unstemmed | The amygdala in value-guided decision making |
| title_short | The amygdala in value-guided decision making |
| title_sort | amygdala in value guided decision making |
| topic | Brain and Cognitive Sciences. |
| url | http://hdl.handle.net/1721.1/114076 |
| work_keys_str_mv | AT jaimebustamantekeankeanwillyams theamygdalainvalueguideddecisionmaking AT jaimebustamantekeankeanwillyams amygdalainvalueguideddecisionmaking |