Concise Total Syntheses of (+)-Haplocidine and (+)-Haplocine via Late-Stage Oxidation of (+)-Fendleridine Derivatives

Concise Total Syntheses of (+)-Haplocidine and (+)-Haplocine via Late-Stage Oxidation of (+)-Fendleridine Derivatives

We report the first total syntheses of (+)-haplocidine and its N1-amide congener (+)-haplocine. Our concise synthesis of these alkaloids required the development of a late-stage and highly selective C-H oxidation of complex aspidosperma alkaloid derivatives. A versatile, amide-directed ortho-acetoxy...

Bibliografski detalji
Glavni autori:	White, Kolby L., Movassaghi, Mohammad
Daljnji autori:	Massachusetts Institute of Technology. Department of Chemistry
Format:	Članak
Izdano:	American Chemical Society (ACS) 2018
Online pristup:	http://hdl.handle.net/1721.1/114276 https://orcid.org/0000-0003-3080-1063

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