Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography
Radiofrequency ablation (RFA) is widely used for the eradication of dysplasia and the treatment of early stage esophageal carcinoma in patients with Barrett's esophagus (BE). However, there are several factors, such as variation of BE epithelium (EP) thickness among individual patients and vary...
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SPIE
2018
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| Online Access: | http://hdl.handle.net/1721.1/114437 https://orcid.org/0000-0002-2976-6195 https://orcid.org/0000-0003-4811-3429 https://orcid.org/0000-0002-0828-4357 |
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| author | Huang, Qin Mashimo, Hiroshi Lee, Hsiang-Chieh Ahsen, Osman Oguz Liu, Jonathan Jaoshin Tsai, Tsung-Han Fujimoto, James G |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Huang, Qin Mashimo, Hiroshi Lee, Hsiang-Chieh Ahsen, Osman Oguz Liu, Jonathan Jaoshin Tsai, Tsung-Han Fujimoto, James G |
| author_sort | Huang, Qin |
| collection | MIT |
| description | Radiofrequency ablation (RFA) is widely used for the eradication of dysplasia and the treatment of early stage esophageal carcinoma in patients with Barrett's esophagus (BE). However, there are several factors, such as variation of BE epithelium (EP) thickness among individual patients and varying RFA catheter-tissue contact, which may compromise RFA efficacy. We used a high-speed optical coherence tomography (OCT) system to identify and monitor changes in the esophageal tissue architecture from RFA. Two different OCT imaging/RFA application protocols were performed using an ex vivo swine esophagus model: (1) post-RFA volumetric OCT imaging for quantitative analysis of the coagulum formation using RFA applications with different energy settings, and (2) M-mode OCT imaging for monitoring the dynamics of tissue architectural changes in real time during RFA application. Post-RFA volumetric OCT measurements showed an increase in the coagulum thickness with respect to the increasing RFA energies. Using a subset of the specimens, OCT measurements of coagulum and coagulum + residual EP thickness were shown to agree with histology, which accounted for specimen shrinkage during histological processing. In addition, we demonstrated the feasibility of OCT for real-time visualization of the architectural changes during RFA application with different energy settings. Results suggest feasibility of using OCT for RFA treatment planning and guidance. |
| first_indexed | 2024-09-23T13:23:48Z |
| format | Article |
| id | mit-1721.1/114437 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T13:23:48Z |
| publishDate | 2018 |
| publisher | SPIE |
| record_format | dspace |
| spelling | mit-1721.1/1144372022-09-28T13:54:08Z Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography Huang, Qin Mashimo, Hiroshi Lee, Hsiang-Chieh Ahsen, Osman Oguz Liu, Jonathan Jaoshin Tsai, Tsung-Han Fujimoto, James G Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Lee, Hsiang-Chieh Ahsen, Osman Oguz Liu, Jonathan Jaoshin Tsai, Tsung-Han Fujimoto, James G Radiofrequency ablation (RFA) is widely used for the eradication of dysplasia and the treatment of early stage esophageal carcinoma in patients with Barrett's esophagus (BE). However, there are several factors, such as variation of BE epithelium (EP) thickness among individual patients and varying RFA catheter-tissue contact, which may compromise RFA efficacy. We used a high-speed optical coherence tomography (OCT) system to identify and monitor changes in the esophageal tissue architecture from RFA. Two different OCT imaging/RFA application protocols were performed using an ex vivo swine esophagus model: (1) post-RFA volumetric OCT imaging for quantitative analysis of the coagulum formation using RFA applications with different energy settings, and (2) M-mode OCT imaging for monitoring the dynamics of tissue architectural changes in real time during RFA application. Post-RFA volumetric OCT measurements showed an increase in the coagulum thickness with respect to the increasing RFA energies. Using a subset of the specimens, OCT measurements of coagulum and coagulum + residual EP thickness were shown to agree with histology, which accounted for specimen shrinkage during histological processing. In addition, we demonstrated the feasibility of OCT for real-time visualization of the architectural changes during RFA application with different energy settings. Results suggest feasibility of using OCT for RFA treatment planning and guidance. National Institutes of Health (U.S.) (Grant R01-CA075289-19) National Institutes of Health (U.S.) (Grant R01-EY011289-30) National Institutes of Health (U.S.) (Grant R01-CA178636-04) United States. Air Force Office of Scientific Research (Award FA9550-15-1-0473) United States. Air Force Office of Scientific Research (Award FA9550-12-1-0499) 2018-03-29T13:48:59Z 2018-03-29T13:48:59Z 2017-07 2017-03 2018-02-23T15:19:28Z Article http://purl.org/eprint/type/JournalArticle 1083-3668 1560-2281 http://hdl.handle.net/1721.1/114437 Lee, Hsiang-Chieh et al. “Assessment of the Radiofrequency Ablation Dynamics of Esophageal Tissue with Optical Coherence Tomography.” Journal of Biomedical Optics 22, 7 (July 2017): 076001 © 2017 The Authors https://orcid.org/0000-0002-2976-6195 https://orcid.org/0000-0003-4811-3429 https://orcid.org/0000-0002-0828-4357 http://dx.doi.org/10.1117/1.JBO.22.7.076001 Journal of Biomedical Optics Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf SPIE Society of Photo-optical Engineers |
| spellingShingle | Huang, Qin Mashimo, Hiroshi Lee, Hsiang-Chieh Ahsen, Osman Oguz Liu, Jonathan Jaoshin Tsai, Tsung-Han Fujimoto, James G Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography |
| title | Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography |
| title_full | Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography |
| title_fullStr | Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography |
| title_full_unstemmed | Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography |
| title_short | Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography |
| title_sort | assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography |
| url | http://hdl.handle.net/1721.1/114437 https://orcid.org/0000-0002-2976-6195 https://orcid.org/0000-0003-4811-3429 https://orcid.org/0000-0002-0828-4357 |
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