Acoel regeneration mechanisms indicate an ancient role for muscle in regenerative patterning
Positional information is required for animal regeneration, yet how it is harbored in adult tissues is poorly understood. In planarians, positional control genes (PCGs) control regeneration outcomes and are regionally expressed predominately in the musculature. Acoels are early diverging bilaterally...
| Main Authors: | , , , |
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| Format: | Article |
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Nature Publishing Group
2018
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| Online Access: | http://hdl.handle.net/1721.1/114708 https://orcid.org/0000-0002-4651-0626 https://orcid.org/0000-0002-5569-333X |
| _version_ | 1826212855830020096 |
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| author | Srivastava, Mansi Salvamoser, Ranja Raz, Amelie A. Reddien, Peter |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Srivastava, Mansi Salvamoser, Ranja Raz, Amelie A. Reddien, Peter |
| author_sort | Srivastava, Mansi |
| collection | MIT |
| description | Positional information is required for animal regeneration, yet how it is harbored in adult tissues is poorly understood. In planarians, positional control genes (PCGs) control regeneration outcomes and are regionally expressed predominately in the musculature. Acoels are early diverging bilaterally symmetric animals, having separated from other bilaterians > 550 million years ago. Here, we find that PCGs in the acoel Hofstenia miamia are expressed together and specifically in a primary differentiated cell type: muscle. The vast majority of Hofstenia muscle cells in regions tested express PCGs, suggesting positional information is a major feature of muscle. PCG expression domains are dynamic in muscle after injury, consistent with known PCG roles in guiding regeneration. These data demonstrate an instructive positional role for Hofstenia muscle and this similarity with planarians suggests mesodermal muscle originated at the base of the Bilateria not only for contraction, but also as the source of positional information guiding regeneration. |
| first_indexed | 2024-09-23T15:38:53Z |
| format | Article |
| id | mit-1721.1/114708 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T15:38:53Z |
| publishDate | 2018 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1147082022-10-02T03:11:04Z Acoel regeneration mechanisms indicate an ancient role for muscle in regenerative patterning Srivastava, Mansi Salvamoser, Ranja Raz, Amelie A. Reddien, Peter Massachusetts Institute of Technology. Department of Biology Raz, Amelie A. Reddien, Peter Positional information is required for animal regeneration, yet how it is harbored in adult tissues is poorly understood. In planarians, positional control genes (PCGs) control regeneration outcomes and are regionally expressed predominately in the musculature. Acoels are early diverging bilaterally symmetric animals, having separated from other bilaterians > 550 million years ago. Here, we find that PCGs in the acoel Hofstenia miamia are expressed together and specifically in a primary differentiated cell type: muscle. The vast majority of Hofstenia muscle cells in regions tested express PCGs, suggesting positional information is a major feature of muscle. PCG expression domains are dynamic in muscle after injury, consistent with known PCG roles in guiding regeneration. These data demonstrate an instructive positional role for Hofstenia muscle and this similarity with planarians suggests mesodermal muscle originated at the base of the Bilateria not only for contraction, but also as the source of positional information guiding regeneration. 2018-04-13T16:42:13Z 2018-04-13T16:42:13Z 2017-10 2017-06 2018-04-09T21:54:20Z Article http://purl.org/eprint/type/JournalArticle 2041-1723 http://hdl.handle.net/1721.1/114708 Raz, Amelie A. et al. “Acoel Regeneration Mechanisms Indicate an Ancient Role for Muscle in Regenerative Patterning.” Nature Communications 8, 1 (October 2017): 1260 © 2017 The Author(s) https://orcid.org/0000-0002-4651-0626 https://orcid.org/0000-0002-5569-333X http://dx.doi.org/10.1038/S41467-017-01148-5 Nature Communications Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ application/pdf Nature Publishing Group Nature |
| spellingShingle | Srivastava, Mansi Salvamoser, Ranja Raz, Amelie A. Reddien, Peter Acoel regeneration mechanisms indicate an ancient role for muscle in regenerative patterning |
| title | Acoel regeneration mechanisms indicate an ancient role for muscle in regenerative patterning |
| title_full | Acoel regeneration mechanisms indicate an ancient role for muscle in regenerative patterning |
| title_fullStr | Acoel regeneration mechanisms indicate an ancient role for muscle in regenerative patterning |
| title_full_unstemmed | Acoel regeneration mechanisms indicate an ancient role for muscle in regenerative patterning |
| title_short | Acoel regeneration mechanisms indicate an ancient role for muscle in regenerative patterning |
| title_sort | acoel regeneration mechanisms indicate an ancient role for muscle in regenerative patterning |
| url | http://hdl.handle.net/1721.1/114708 https://orcid.org/0000-0002-4651-0626 https://orcid.org/0000-0002-5569-333X |
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