Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation
Targeted transcriptional regulation is a powerful tool to study genetic mediators of cellular behavior. Here, we show that catalytically dead Cas9 (dCas9) targeted to genomic regions upstream or downstream of the transcription start site allows for specific and sustainable gene-expression level alte...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Published: |
National Academy of Sciences (U.S.)
2018
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| Online Access: | http://hdl.handle.net/1721.1/114928 https://orcid.org/0000-0002-5229-8748 https://orcid.org/0000-0003-3383-0118 |