Water Distribution, Dynamics, and Interactions with Alzheimer’s β-Amyloid Fibrils Investigated by Solid-State NMR
Water is essential for protein folding and assembly of amyloid fibrils. Internal water cavities have been proposed for several amyloid fibrils, but no direct structural and dynamical data have been reported on the water dynamics and site-specific interactions of water with the fibrils. Here we use s...
Main Authors: | Wang, Tuo, Jo, Hyunil, DeGrado, William F., Hong, Mei |
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Other Authors: | Massachusetts Institute of Technology. Department of Chemistry |
Format: | Article |
Language: | en_US |
Published: |
American Chemical Society (ACS)
2018
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Online Access: | http://hdl.handle.net/1721.1/114965 https://orcid.org/0000-0002-1801-924X https://orcid.org/0000-0001-5255-5858 |
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