Steady states in rapidly evolving populations
Thesis: S.M., Massachusetts Institute of Technology, Department of Physics, 2017.
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| Other Authors: | |
| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2018
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| Online Access: | http://hdl.handle.net/1721.1/115020 |
| _version_ | 1811077858568699904 |
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| author | Melissa, Matthew (Matthew J.) |
| author2 | Mehran Kardar. |
| author_facet | Mehran Kardar. Melissa, Matthew (Matthew J.) |
| author_sort | Melissa, Matthew (Matthew J.) |
| collection | MIT |
| description | Thesis: S.M., Massachusetts Institute of Technology, Department of Physics, 2017. |
| first_indexed | 2024-09-23T10:49:24Z |
| format | Thesis |
| id | mit-1721.1/115020 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T10:49:24Z |
| publishDate | 2018 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/1150202019-04-12T19:35:20Z Steady states in rapidly evolving populations Melissa, Matthew (Matthew J.) Mehran Kardar. Massachusetts Institute of Technology. Department of Physics. Massachusetts Institute of Technology. Department of Physics. Physics. Thesis: S.M., Massachusetts Institute of Technology, Department of Physics, 2017. Cataloged from PDF version of thesis. Includes bibliographical references (pages 63-68). Populations are subject to mutations conferring beneficial effects, as well as mutations conferring deleterious effects. Even if deleterious mutations occur much more frequently than beneficial mutations, the contribution of deleterious mutations to the overall rate of change of the population-wide mean fitness may be limited, due to the efficient action of selection. However, in particularly rapidly evolving populations, the stochastic accumulation of deleterious mutations may negate a significant fraction of the fitness increments provided by beneficial mutations, or even result in an overall decrease in fitness over time. Here we obtain a constraint on beneficial and deleterious mutation rates and selection pressures in order for positive adaptation to counterbalance fitness decline via Muller's ratchet. The steady state that separates parameter regimes of positive adaptation and negative adaptation is characterized by appealing to the exponential dependence of fixation probabilities on fitness effect sizes. We consider a range of fitness-mediated epistatic interactions and the corresponding implications regarding the existence, location and stability of long-term evolutionary fixed points. by Matthew Melissa. S.M. 2018-04-27T18:10:20Z 2018-04-27T18:10:20Z 2017 2017 Thesis http://hdl.handle.net/1721.1/115020 1031218213 eng MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. http://dspace.mit.edu/handle/1721.1/7582 68 pages application/pdf Massachusetts Institute of Technology |
| spellingShingle | Physics. Melissa, Matthew (Matthew J.) Steady states in rapidly evolving populations |
| title | Steady states in rapidly evolving populations |
| title_full | Steady states in rapidly evolving populations |
| title_fullStr | Steady states in rapidly evolving populations |
| title_full_unstemmed | Steady states in rapidly evolving populations |
| title_short | Steady states in rapidly evolving populations |
| title_sort | steady states in rapidly evolving populations |
| topic | Physics. |
| url | http://hdl.handle.net/1721.1/115020 |
| work_keys_str_mv | AT melissamatthewmatthewj steadystatesinrapidlyevolvingpopulations |