Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes
Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencap-sulate islets from different...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Published: |
National Academy of Sciences (U.S.)
2018
|
| Online Access: | http://hdl.handle.net/1721.1/115205 https://orcid.org/0000-0001-8777-9632 |
| _version_ | 1811078841134743552 |
|---|---|
| author | Ludwig, Barbara Ludwig, Stefan Steffen, Anja Knauf, Yvonne Zimerman, Baruch Heinke, Sophie Lehmann, Susann Schubert, Undine Schmid, Janine Bleyer, Martina Schönmann, Uwe Bonifacio, Ezio Solimena, Michele Reichel, Andreas Schally, Andrew V. Rotem, Avi Barkai, Uriel Grinberg-Rashi, Helena Kaup, Franz-Josef Avni, Yuval Jones, Peter Bornstein, Stefan R. Colton, Clark K |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Ludwig, Barbara Ludwig, Stefan Steffen, Anja Knauf, Yvonne Zimerman, Baruch Heinke, Sophie Lehmann, Susann Schubert, Undine Schmid, Janine Bleyer, Martina Schönmann, Uwe Bonifacio, Ezio Solimena, Michele Reichel, Andreas Schally, Andrew V. Rotem, Avi Barkai, Uriel Grinberg-Rashi, Helena Kaup, Franz-Josef Avni, Yuval Jones, Peter Bornstein, Stefan R. Colton, Clark K |
| author_sort | Ludwig, Barbara |
| collection | MIT |
| description | Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencap-sulate islets from different sources that allow their survival and function without immunosuppression. Here we report successful and safe transplantation of porcine islets with a bioartificial pancreas device in diabetic primates without any immune suppression. This strategy should lead to pioneering clinical trials with xenotransplantation for treatment of diabetes and, thereby, represents a previously unidentified approach to efficient cell replacement for a broad spectrum of endocrine disorders and other organ dysfunctions. Keywords: diabetes; porcine islets; beta-cell replacement; immune barrier |
| first_indexed | 2024-09-23T11:06:14Z |
| format | Article |
| id | mit-1721.1/115205 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T11:06:14Z |
| publishDate | 2018 |
| publisher | National Academy of Sciences (U.S.) |
| record_format | dspace |
| spelling | mit-1721.1/1152052022-10-01T01:16:17Z Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes Ludwig, Barbara Ludwig, Stefan Steffen, Anja Knauf, Yvonne Zimerman, Baruch Heinke, Sophie Lehmann, Susann Schubert, Undine Schmid, Janine Bleyer, Martina Schönmann, Uwe Bonifacio, Ezio Solimena, Michele Reichel, Andreas Schally, Andrew V. Rotem, Avi Barkai, Uriel Grinberg-Rashi, Helena Kaup, Franz-Josef Avni, Yuval Jones, Peter Bornstein, Stefan R. Colton, Clark K Massachusetts Institute of Technology. Department of Chemical Engineering Colton, Clark K Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencap-sulate islets from different sources that allow their survival and function without immunosuppression. Here we report successful and safe transplantation of porcine islets with a bioartificial pancreas device in diabetic primates without any immune suppression. This strategy should lead to pioneering clinical trials with xenotransplantation for treatment of diabetes and, thereby, represents a previously unidentified approach to efficient cell replacement for a broad spectrum of endocrine disorders and other organ dysfunctions. Keywords: diabetes; porcine islets; beta-cell replacement; immune barrier 2018-05-03T15:46:57Z 2018-05-03T15:46:57Z 2017-10 2017-05 2018-04-26T17:09:49Z Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/115205 Ludwig, Barbara et al. “Favorable Outcome of Experimental Islet Xenotransplantation Without Immunosuppression in a Nonhuman Primate Model of Diabetes.” Proceedings of the National Academy of Sciences 114, 44 (October 2017): 11745–11750 © 2017 National Academy of Sciences https://orcid.org/0000-0001-8777-9632 http://dx.doi.org/10.1073/PNAS.1708420114 Proceedings of the National Academy of Sciences Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences (U.S.) PNAS |
| spellingShingle | Ludwig, Barbara Ludwig, Stefan Steffen, Anja Knauf, Yvonne Zimerman, Baruch Heinke, Sophie Lehmann, Susann Schubert, Undine Schmid, Janine Bleyer, Martina Schönmann, Uwe Bonifacio, Ezio Solimena, Michele Reichel, Andreas Schally, Andrew V. Rotem, Avi Barkai, Uriel Grinberg-Rashi, Helena Kaup, Franz-Josef Avni, Yuval Jones, Peter Bornstein, Stefan R. Colton, Clark K Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes |
| title | Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes |
| title_full | Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes |
| title_fullStr | Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes |
| title_full_unstemmed | Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes |
| title_short | Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes |
| title_sort | favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes |
| url | http://hdl.handle.net/1721.1/115205 https://orcid.org/0000-0001-8777-9632 |
| work_keys_str_mv | AT ludwigbarbara favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes AT ludwigstefan favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes AT steffenanja favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes AT knaufyvonne favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes AT zimermanbaruch favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes AT heinkesophie favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes AT lehmannsusann favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes AT schubertundine favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes AT schmidjanine favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes AT bleyermartina favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes AT schonmannuwe favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes AT bonifacioezio favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes AT solimenamichele favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes AT reichelandreas favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes AT schallyandrewv favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes AT rotemavi favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes AT barkaiuriel favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes AT grinbergrashihelena favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes AT kaupfranzjosef favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes AT avniyuval favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes AT jonespeter favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes AT bornsteinstefanr favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes AT coltonclarkk favorableoutcomeofexperimentalisletxenotransplantationwithoutimmunosuppressioninanonhumanprimatemodelofdiabetes |