Experience-dependent synaptic plasticity in V1 occurs without microglial CX3CR1
Brief monocular deprivation (MD) shifts ocular dominance and reduces the density of thalamic synapses in layer 4 of the mouse primary visual cortex (V1). We found that microglial lysosome content is also increased as a result of MD. Previous studies have shown that the microglial fractalkine recepto...
| Main Authors: | , , , , , |
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| Format: | Article |
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Society for Neuroscience
2018
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| Online Access: | http://hdl.handle.net/1721.1/115288 https://orcid.org/0000-0003-1986-4207 |
| _version_ | 1811072451137765376 |
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| author | Maher, Erin E. Welsh, Christina A. Stevens, Beth Erisir, Alev Schecter, Rachel Ward Bear, Mark |
| author2 | Picower Institute for Learning and Memory |
| author_facet | Picower Institute for Learning and Memory Maher, Erin E. Welsh, Christina A. Stevens, Beth Erisir, Alev Schecter, Rachel Ward Bear, Mark |
| author_sort | Maher, Erin E. |
| collection | MIT |
| description | Brief monocular deprivation (MD) shifts ocular dominance and reduces the density of thalamic synapses in layer 4 of the mouse primary visual cortex (V1). We found that microglial lysosome content is also increased as a result of MD. Previous studies have shown that the microglial fractalkine receptor CX3CR1 is involved in synaptic development and hippocampal plasticity.Wetherefore tested the hypothesis that neuron-to-microglial communication via CX3CR1 is an essential component of visual cortical development and plasticity in male mice. Our data show that CX3CR1 is not required for normal development of V1 responses to visual stimulation, multiple forms of experience-dependent plasticity, or the synapse loss that accompanies MD in layer 4. By ruling out an essential role for fractalkine signaling, our study narrows the search for understanding how microglia respond to active synapse modification in the visual cortex. Keywords: microglia; ocular dominance plasticity; stimulus-selective response potentiation; synaptic plasticity; visual cortex |
| first_indexed | 2024-09-23T09:06:09Z |
| format | Article |
| id | mit-1721.1/115288 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T09:06:09Z |
| publishDate | 2018 |
| publisher | Society for Neuroscience |
| record_format | dspace |
| spelling | mit-1721.1/1152882022-09-26T10:29:17Z Experience-dependent synaptic plasticity in V1 occurs without microglial CX3CR1 Maher, Erin E. Welsh, Christina A. Stevens, Beth Erisir, Alev Schecter, Rachel Ward Bear, Mark Picower Institute for Learning and Memory Schecter, Rachel Ward Bear, Mark Brief monocular deprivation (MD) shifts ocular dominance and reduces the density of thalamic synapses in layer 4 of the mouse primary visual cortex (V1). We found that microglial lysosome content is also increased as a result of MD. Previous studies have shown that the microglial fractalkine receptor CX3CR1 is involved in synaptic development and hippocampal plasticity.Wetherefore tested the hypothesis that neuron-to-microglial communication via CX3CR1 is an essential component of visual cortical development and plasticity in male mice. Our data show that CX3CR1 is not required for normal development of V1 responses to visual stimulation, multiple forms of experience-dependent plasticity, or the synapse loss that accompanies MD in layer 4. By ruling out an essential role for fractalkine signaling, our study narrows the search for understanding how microglia respond to active synapse modification in the visual cortex. Keywords: microglia; ocular dominance plasticity; stimulus-selective response potentiation; synaptic plasticity; visual cortex National Institutes of Health (U.S.) (Grant R01-EY012309) National Institutes of Health (U.S.) (Grant R01-EY0237) 2018-05-10T14:37:06Z 2018-05-10T14:37:06Z 2017-11 2017-09 2018-05-04T15:37:57Z Article http://purl.org/eprint/type/JournalArticle 0270-6474 1529-2401 http://hdl.handle.net/1721.1/115288 Schecter, Rachel W. et al. “Experience-Dependent Synaptic Plasticity in V1 Occurs Without Microglial CX3CR1.” The Journal of Neuroscience (September 2017): 2679–16 © 2017 The Authors https://orcid.org/0000-0003-1986-4207 http://dx.doi.org/10.1523/JNEUROSCI.2679-16.2017 Journal of Neuroscience Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/ application/pdf Society for Neuroscience Society for Neuroscience |
| spellingShingle | Maher, Erin E. Welsh, Christina A. Stevens, Beth Erisir, Alev Schecter, Rachel Ward Bear, Mark Experience-dependent synaptic plasticity in V1 occurs without microglial CX3CR1 |
| title | Experience-dependent synaptic plasticity in V1 occurs without microglial CX3CR1 |
| title_full | Experience-dependent synaptic plasticity in V1 occurs without microglial CX3CR1 |
| title_fullStr | Experience-dependent synaptic plasticity in V1 occurs without microglial CX3CR1 |
| title_full_unstemmed | Experience-dependent synaptic plasticity in V1 occurs without microglial CX3CR1 |
| title_short | Experience-dependent synaptic plasticity in V1 occurs without microglial CX3CR1 |
| title_sort | experience dependent synaptic plasticity in v1 occurs without microglial cx3cr1 |
| url | http://hdl.handle.net/1721.1/115288 https://orcid.org/0000-0003-1986-4207 |
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