High speed swept source optical coherence tomography handheld instrument at 1310nm for point-of-care imaging
Thesis: S.M., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2018
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| Online Access: | http://hdl.handle.net/1721.1/115735 |
| _version_ | 1811097515246747648 |
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| author | Yiu, Patrick (Patrick Wai-Kit) |
| author2 | James G. Fujimoto. |
| author_facet | James G. Fujimoto. Yiu, Patrick (Patrick Wai-Kit) |
| author_sort | Yiu, Patrick (Patrick Wai-Kit) |
| collection | MIT |
| description | Thesis: S.M., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018. |
| first_indexed | 2024-09-23T17:00:36Z |
| format | Thesis |
| id | mit-1721.1/115735 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T17:00:36Z |
| publishDate | 2018 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/1157352019-04-10T08:40:31Z High speed swept source optical coherence tomography handheld instrument at 1310nm for point-of-care imaging High speed swept source OCT handheld instrument at 1310nm for point-of-care imaging Yiu, Patrick (Patrick Wai-Kit) James G. Fujimoto. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science. Electrical Engineering and Computer Science. Thesis: S.M., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018. Cataloged from PDF version of thesis. Includes bibliographical references. Optical coherence tomography (OCT) is a novel biomedical imaging technique that functions as a type of "optical biopsy" by using low coherence interferometry to non-invasively generate high resolution cross-sectional images of tissue in real time. OCT has become a standard diagnostic tool in ophthalmology and investigators have demonstrated OCT in a variety of biomedical applications including cardiology, gastroenterology, dermatology, and urology. Recent research advances in swept source lasers have enabled swept source OCT (SS-OCT) to achieve imaging speeds 5-50x faster than commercially available spectral domain OCT (SD-OCT) systems. This thesis describes the design of a handheld SS-OCT instrument for portable-real-time imaging in situ at the point of care. Traditional OCT devices require bulky table-mounted systems, but the handheld device has the potential to be used as an advanced point-of-care diagnostic instrument in primary care settings or intraoperatively. The combination of the wide scanning angle in the handheld and the high imaging speed of SS-OCT could allow for screening of pathology with a single volumetric data set spanning the areas of interest on the patient. The compact, easy-to-use form factor could enable the adoption of SS-OCT in settings like primary care clinics or the surgical theater where space is limited. Emergent applications can include intraoperative assessment of kidney transplant viability, as many donor kidneys suffer ischemic insult while awaiting transplant and there is a critical clinical need for a reliable, real-time assay to evaluate donor kidney viability and predict post-transplant outcome. by Patrick Yiu. S.M. 2018-05-23T16:32:27Z 2018-05-23T16:32:27Z 2018 2018 Thesis http://hdl.handle.net/1721.1/115735 1036986720 eng MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. http://dspace.mit.edu/handle/1721.1/7582 117 pages application/pdf Massachusetts Institute of Technology |
| spellingShingle | Electrical Engineering and Computer Science. Yiu, Patrick (Patrick Wai-Kit) High speed swept source optical coherence tomography handheld instrument at 1310nm for point-of-care imaging |
| title | High speed swept source optical coherence tomography handheld instrument at 1310nm for point-of-care imaging |
| title_full | High speed swept source optical coherence tomography handheld instrument at 1310nm for point-of-care imaging |
| title_fullStr | High speed swept source optical coherence tomography handheld instrument at 1310nm for point-of-care imaging |
| title_full_unstemmed | High speed swept source optical coherence tomography handheld instrument at 1310nm for point-of-care imaging |
| title_short | High speed swept source optical coherence tomography handheld instrument at 1310nm for point-of-care imaging |
| title_sort | high speed swept source optical coherence tomography handheld instrument at 1310nm for point of care imaging |
| topic | Electrical Engineering and Computer Science. |
| url | http://hdl.handle.net/1721.1/115735 |
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