Differential Regulation of Effector- and Central-Memory Responses to Toxoplasma gondii Infection by IL-12 Revealed by Tracking of Tgd057-Specific CD8+ T Cells

Differential Regulation of Effector- and Central-Memory Responses to Toxoplasma gondii Infection by IL-12 Revealed by Tracking of Tgd057-Specific CD8+ T Cells

Production of the pro-inflammatory cytokine IL-12 by innate phagocytes drives the differentiation of IFN-γ-producing effector T cells during Toxoplasma gondii infection. However, the role of IL-12 in the regulation of memory CD8+ T cell differentiation and function during murine toxoplasmosis is unc...

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Bibliographic Details
Main Authors: Wilson, Douglas C., Grotenbreg, Gijsbert M., Liu, Kenian, Zhao, Yanlin, Frickel, Eva-Maria, Gubbels, Marc-Jan, Yap, George S., Ploegh, Hidde
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Public Library of Science (PLoS) 2018
Online Access:http://hdl.handle.net/1721.1/116198
https://orcid.org/0000-0002-1090-6071

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