Stalled Spliceosomes Are a Signal for RNAi-Mediated Genome Defense

Stalled Spliceosomes Are a Signal for RNAi-Mediated Genome Defense

Using the yeast Cryptococcus neoformans, we describe a mechanism by which transposons are initially targeted for RNAi-mediated genome defense. We show that intron-containing mRNA precursors template siRNA synthesis. We identify a Spliceosome-Coupled And Nuclear RNAi (SCANR) complex required for siRN...

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Bibliographic Details
Main Authors: Dumesic, Phillip A., Natarajan, Prashanthi, Chen, Changbin, Drinnenberg, Ines A., Schiller, Benjamin J., Thompson, James, Moresco, James J., Yates, John R., Madhani, Hiten D., Bartel, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Elsevier BV 2018
Online Access:http://hdl.handle.net/1721.1/116327
https://orcid.org/0000-0002-3872-2856

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