Frequency-Swept Integrated Solid Effect
The efficiency of continuous wave dynamic nuclear polarization (DNP) experiments decreases at the high magnetic fields used in contemporary high-resolution NMR applications. To recover the expected signal enhancements from DNP, we explored time domain experiments such as NOVEL which matches the elec...
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| Médium: | Článek |
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Wiley-Blackwell
2018
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| On-line přístup: | http://hdl.handle.net/1721.1/116386 https://orcid.org/0000-0001-9092-612X https://orcid.org/0000-0003-1589-832X |
| _version_ | 1826217101092716544 |
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| author | Walish, Joseph J. Can, Thach V Walish, Joseph John Swager, Timothy M Griffin, Robert Guy |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Walish, Joseph J. Can, Thach V Walish, Joseph John Swager, Timothy M Griffin, Robert Guy |
| author_sort | Walish, Joseph J. |
| collection | MIT |
| description | The efficiency of continuous wave dynamic nuclear polarization (DNP) experiments decreases at the high magnetic fields used in contemporary high-resolution NMR applications. To recover the expected signal enhancements from DNP, we explored time domain experiments such as NOVEL which matches the electron Rabi frequency to the nuclear Larmor frequency to mediate polarization transfer. However, satisfying this matching condition at high frequencies is technically demanding. As an alternative we report here frequency-swept integrated solid effect (FS-ISE) experiments that allow low power sweeps of the exciting microwave frequencies to constructively integrate the negative and positive polarizations of the solid effect, thereby producing a polarization efficiency comparable to (±10 % difference) NOVEL. Finally, the microwave frequency modulation results in field profiles that exhibit new features that we coin the “stretched” solid effect. |
| first_indexed | 2024-09-23T16:58:01Z |
| format | Article |
| id | mit-1721.1/116386 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T16:58:01Z |
| publishDate | 2018 |
| publisher | Wiley-Blackwell |
| record_format | dspace |
| spelling | mit-1721.1/1163862022-09-29T22:45:59Z Frequency-Swept Integrated Solid Effect Walish, Joseph J. Can, Thach V Walish, Joseph John Swager, Timothy M Griffin, Robert Guy Massachusetts Institute of Technology. Department of Chemistry Francis Bitter Magnet Laboratory (Massachusetts Institute of Technology) Can, Thach V Walish, Joseph John Swager, Timothy M Griffin, Robert Guy The efficiency of continuous wave dynamic nuclear polarization (DNP) experiments decreases at the high magnetic fields used in contemporary high-resolution NMR applications. To recover the expected signal enhancements from DNP, we explored time domain experiments such as NOVEL which matches the electron Rabi frequency to the nuclear Larmor frequency to mediate polarization transfer. However, satisfying this matching condition at high frequencies is technically demanding. As an alternative we report here frequency-swept integrated solid effect (FS-ISE) experiments that allow low power sweeps of the exciting microwave frequencies to constructively integrate the negative and positive polarizations of the solid effect, thereby producing a polarization efficiency comparable to (±10 % difference) NOVEL. Finally, the microwave frequency modulation results in field profiles that exhibit new features that we coin the “stretched” solid effect. National Institute of Biomedical Imaging and Bioengineering (U.S.) (Grant EB-002804) National Institute of Biomedical Imaging and Bioengineering (U.S.) (Grant EB-002026) National Institute of General Medical Sciences (U.S.) (Grant GM095843) 2018-06-18T20:30:34Z 2018-06-18T20:30:34Z 2017-06 2017-04 2018-06-15T12:26:04Z Article http://purl.org/eprint/type/JournalArticle 1433-7851 1521-3773 http://hdl.handle.net/1721.1/116386 Can, Thach V. et al. “Frequency-Swept Integrated Solid Effect.” Angewandte Chemie International Edition 56, 24 (May 2017): 6744–6748 © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim https://orcid.org/0000-0001-9092-612X https://orcid.org/0000-0003-1589-832X http://dx.doi.org/10.1002/ANIE.201700032 Angewandte Chemie International Edition Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley-Blackwell PMC |
| spellingShingle | Walish, Joseph J. Can, Thach V Walish, Joseph John Swager, Timothy M Griffin, Robert Guy Frequency-Swept Integrated Solid Effect |
| title | Frequency-Swept Integrated Solid Effect |
| title_full | Frequency-Swept Integrated Solid Effect |
| title_fullStr | Frequency-Swept Integrated Solid Effect |
| title_full_unstemmed | Frequency-Swept Integrated Solid Effect |
| title_short | Frequency-Swept Integrated Solid Effect |
| title_sort | frequency swept integrated solid effect |
| url | http://hdl.handle.net/1721.1/116386 https://orcid.org/0000-0001-9092-612X https://orcid.org/0000-0003-1589-832X |
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