It takes two to tango: NAD+ and sirtuins in aging/longevity control
The coupling of nicotinamide adenine dinucleotide (NAD⁺) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD⁺ and sirtuins has an ancient origin and provides a mechanistic foundation that translates the regulation of...
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| Format: | Article |
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Springer Nature
2018
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| Online Access: | http://hdl.handle.net/1721.1/116435 https://orcid.org/0000-0003-4064-2510 |
| _version_ | 1826195363795566592 |
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| author | Imai, Shin-ichiro Guarente, Leonard Pershing |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Imai, Shin-ichiro Guarente, Leonard Pershing |
| author_sort | Imai, Shin-ichiro |
| collection | MIT |
| description | The coupling of nicotinamide adenine dinucleotide (NAD⁺) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD⁺ and sirtuins has an ancient origin and provides a mechanistic foundation that translates the regulation of energy metabolism into aging and longevity control in diverse organisms. Although the field of sirtuin research went through intensive controversies, an increasing number of recent studies have put those controversies to rest and fully established the significance of sirtuins as an evolutionarily conserved aging/longevity regulator. The tight connection between NAD⁺ and sirtuins is regulated at several different levels, adding further complexity to their coordination in metabolic and aging/longevity control. Interestingly, it has been demonstrated that NAD⁺ availability decreases over age, reducing sirtuin activities and affecting the communication between the nucleus and mitochondria at a cellular level and also between the hypothalamus and adipose tissue at a systemic level. These dynamic cellular and systemic processes likely contribute to the development of age-associated functional decline and the pathogenesis of diseases of aging. To mitigate these age-associated problems, supplementation of key NAD⁺ intermediates is currently drawing significant attention. In this review article, we will summarize these important aspects of the intimate connection between NAD⁺ and sirtuins in aging/longevity control. |
| first_indexed | 2024-09-23T10:11:31Z |
| format | Article |
| id | mit-1721.1/116435 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T10:11:31Z |
| publishDate | 2018 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | mit-1721.1/1164352022-09-30T19:30:23Z It takes two to tango: NAD+ and sirtuins in aging/longevity control Imai, Shin-ichiro Guarente, Leonard Pershing Massachusetts Institute of Technology. Department of Biology Paul F. Glenn Center for Biology of Aging Research (Massachusetts Institute of Technology) Koch Institute for Integrative Cancer Research at MIT Guarente, Leonard Pershing The coupling of nicotinamide adenine dinucleotide (NAD⁺) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD⁺ and sirtuins has an ancient origin and provides a mechanistic foundation that translates the regulation of energy metabolism into aging and longevity control in diverse organisms. Although the field of sirtuin research went through intensive controversies, an increasing number of recent studies have put those controversies to rest and fully established the significance of sirtuins as an evolutionarily conserved aging/longevity regulator. The tight connection between NAD⁺ and sirtuins is regulated at several different levels, adding further complexity to their coordination in metabolic and aging/longevity control. Interestingly, it has been demonstrated that NAD⁺ availability decreases over age, reducing sirtuin activities and affecting the communication between the nucleus and mitochondria at a cellular level and also between the hypothalamus and adipose tissue at a systemic level. These dynamic cellular and systemic processes likely contribute to the development of age-associated functional decline and the pathogenesis of diseases of aging. To mitigate these age-associated problems, supplementation of key NAD⁺ intermediates is currently drawing significant attention. In this review article, we will summarize these important aspects of the intimate connection between NAD⁺ and sirtuins in aging/longevity control. National Institute on Aging (Grant AG037457) National Institute on Aging (Grant AG047902) 2018-06-19T19:29:30Z 2018-06-19T19:29:30Z 2016-08 2016-05 2018-06-19T13:38:29Z Article http://purl.org/eprint/type/JournalArticle 2056-3973 http://hdl.handle.net/1721.1/116435 Imai, Shin-ichiro and Leonard Guarente. “It Takes Two to Tango: NAD+ and Sirtuins in Aging/longevity Control.” Npj Aging and Mechanisms of Disease 2, 1 (August 2016): 16017 © 2016 The Author(s) https://orcid.org/0000-0003-4064-2510 http://dx.doi.org/10.1038/NPJAMD.2016.17 npj Aging and Mechanisms of Disease Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ application/pdf Springer Nature Nature |
| spellingShingle | Imai, Shin-ichiro Guarente, Leonard Pershing It takes two to tango: NAD+ and sirtuins in aging/longevity control |
| title | It takes two to tango: NAD+ and sirtuins in aging/longevity control |
| title_full | It takes two to tango: NAD+ and sirtuins in aging/longevity control |
| title_fullStr | It takes two to tango: NAD+ and sirtuins in aging/longevity control |
| title_full_unstemmed | It takes two to tango: NAD+ and sirtuins in aging/longevity control |
| title_short | It takes two to tango: NAD+ and sirtuins in aging/longevity control |
| title_sort | it takes two to tango nad and sirtuins in aging longevity control |
| url | http://hdl.handle.net/1721.1/116435 https://orcid.org/0000-0003-4064-2510 |
| work_keys_str_mv | AT imaishinichiro ittakestwototangonadandsirtuinsinaginglongevitycontrol AT guarenteleonardpershing ittakestwototangonadandsirtuinsinaginglongevitycontrol |