The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition
In a recent report published in Cancer Discovery we identified a novel vulnerability of cancer cells that have undergone an epithelial–mesenchymal transition (EMT) and established that the PERK branch of the unfolded protein response is constitutively activated upon EMT. In this commentary, we summa...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
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Informa UK Limited
2018
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| Online Access: | http://hdl.handle.net/1721.1/116526 https://orcid.org/0000-0002-2988-0537 https://orcid.org/0000-0002-9703-1780 |
| Summary: | In a recent report published in Cancer Discovery we identified a novel vulnerability of cancer cells that have undergone an epithelial–mesenchymal transition (EMT) and established that the PERK branch of the unfolded protein response is constitutively activated upon EMT. In this commentary, we summarize and provide context for our findings. Keywords: EMT; ER stress; UPR |
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