The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition
In a recent report published in Cancer Discovery we identified a novel vulnerability of cancer cells that have undergone an epithelial–mesenchymal transition (EMT) and established that the PERK branch of the unfolded protein response is constitutively activated upon EMT. In this commentary, we summa...
| Main Authors: | , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Published: |
Informa UK Limited
2018
|
| Online Access: | http://hdl.handle.net/1721.1/116526 https://orcid.org/0000-0002-2988-0537 https://orcid.org/0000-0002-9703-1780 |
| _version_ | 1811073194110484480 |
|---|---|
| author | Feng, Yu-xiong Sokol, Ethan Samuel Gupta, Piyush |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Feng, Yu-xiong Sokol, Ethan Samuel Gupta, Piyush |
| author_sort | Feng, Yu-xiong |
| collection | MIT |
| description | In a recent report published in Cancer Discovery we identified a novel vulnerability of cancer cells that have undergone an epithelial–mesenchymal transition (EMT) and established that the PERK branch of the unfolded protein response is constitutively activated upon EMT. In this commentary, we summarize and provide context for our findings. Keywords: EMT; ER stress; UPR |
| first_indexed | 2024-09-23T09:29:51Z |
| format | Article |
| id | mit-1721.1/116526 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T09:29:51Z |
| publishDate | 2018 |
| publisher | Informa UK Limited |
| record_format | dspace |
| spelling | mit-1721.1/1165262022-09-30T14:49:25Z The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition Feng, Yu-xiong Sokol, Ethan Samuel Gupta, Piyush Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Sokol, Ethan Samuel Gupta, Piyush In a recent report published in Cancer Discovery we identified a novel vulnerability of cancer cells that have undergone an epithelial–mesenchymal transition (EMT) and established that the PERK branch of the unfolded protein response is constitutively activated upon EMT. In this commentary, we summarize and provide context for our findings. Keywords: EMT; ER stress; UPR National Science Foundation (U.S.) (Grant 1122374) 2018-06-22T17:13:00Z 2018-06-22T17:13:00Z 2014-10 2014-09 2018-06-20T18:28:07Z Article http://purl.org/eprint/type/JournalArticle 2372-3556 http://hdl.handle.net/1721.1/116526 Feng, Yu-xiong et al. “The Endoplasmic Reticulum May Be an Achilles’ Heel of Cancer Cells That Have Undergone an Epithelial-to-Mesenchymal Transition.” Molecular & Cellular Oncology 1, 2 (June 2014): e961822 © 2014 The Authors https://orcid.org/0000-0002-2988-0537 https://orcid.org/0000-0002-9703-1780 http://dx.doi.org/10.4161/23723548.2014.961822 Molecular & Cellular Oncology Creative Commons Attribution-NonCommercial 3.0 Unported https://creativecommons.org/licenses/by-nc/3.0/ application/pdf Informa UK Limited Taylor & Francis |
| spellingShingle | Feng, Yu-xiong Sokol, Ethan Samuel Gupta, Piyush The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition |
| title | The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition |
| title_full | The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition |
| title_fullStr | The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition |
| title_full_unstemmed | The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition |
| title_short | The endoplasmic reticulum may be an Achilles' heel of cancer cells that have undergone an epithelial-to-mesenchymal transition |
| title_sort | endoplasmic reticulum may be an achilles heel of cancer cells that have undergone an epithelial to mesenchymal transition |
| url | http://hdl.handle.net/1721.1/116526 https://orcid.org/0000-0002-2988-0537 https://orcid.org/0000-0002-9703-1780 |
| work_keys_str_mv | AT fengyuxiong theendoplasmicreticulummaybeanachillesheelofcancercellsthathaveundergoneanepithelialtomesenchymaltransition AT sokolethansamuel theendoplasmicreticulummaybeanachillesheelofcancercellsthathaveundergoneanepithelialtomesenchymaltransition AT guptapiyush theendoplasmicreticulummaybeanachillesheelofcancercellsthathaveundergoneanepithelialtomesenchymaltransition AT fengyuxiong endoplasmicreticulummaybeanachillesheelofcancercellsthathaveundergoneanepithelialtomesenchymaltransition AT sokolethansamuel endoplasmicreticulummaybeanachillesheelofcancercellsthathaveundergoneanepithelialtomesenchymaltransition AT guptapiyush endoplasmicreticulummaybeanachillesheelofcancercellsthathaveundergoneanepithelialtomesenchymaltransition |