SH3PXD2A (SH3 and PX domains 2A)
The TKS5 protein, encoded by the gene SH3PXD2A, is a scaffolding protein essential for the formation of podosomes and invadopodia in untransformed cells and cancer cells, respectively. Podosomes and invadopodia (which collectively are termed invadosomes) are actin-rich cellular protrusions capable o...
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| Format: | Article |
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INIST-CNRS
2018
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| Online Access: | http://hdl.handle.net/1721.1/116550 https://orcid.org/0000-0001-5785-8911 |
| _version_ | 1826216262159564800 |
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| author | Li, Carman Man Chung Jacks, Tyler E. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Li, Carman Man Chung Jacks, Tyler E. |
| author_sort | Li, Carman Man Chung |
| collection | MIT |
| description | The TKS5 protein, encoded by the gene SH3PXD2A, is a scaffolding protein essential for the formation of podosomes and invadopodia in untransformed cells and cancer cells, respectively. Podosomes and invadopodia (which collectively are termed invadosomes) are actin-rich cellular protrusions capable of secreting proteolytic enzymes that can degrade the extracellular matrix. These structures are thought to regulate cellular migration and invasion, as well as adhesion and the release of growth factors. In the context of cancer, TKS5-dependent invadopodia activity has been shown to play important roles in tumor growth and metastasis in various cancer types. Multiple isoforms of TKS5 exist due to alternative mRNA splicing and promoter usage. |
| first_indexed | 2024-09-23T16:44:53Z |
| format | Article |
| id | mit-1721.1/116550 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T16:44:53Z |
| publishDate | 2018 |
| publisher | INIST-CNRS |
| record_format | dspace |
| spelling | mit-1721.1/1165502022-09-29T21:14:37Z SH3PXD2A (SH3 and PX domains 2A) Li, Carman Man Chung Jacks, Tyler E. Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Li, Carman Man Chung Jacks, Tyler E. The TKS5 protein, encoded by the gene SH3PXD2A, is a scaffolding protein essential for the formation of podosomes and invadopodia in untransformed cells and cancer cells, respectively. Podosomes and invadopodia (which collectively are termed invadosomes) are actin-rich cellular protrusions capable of secreting proteolytic enzymes that can degrade the extracellular matrix. These structures are thought to regulate cellular migration and invasion, as well as adhesion and the release of growth factors. In the context of cancer, TKS5-dependent invadopodia activity has been shown to play important roles in tumor growth and metastasis in various cancer types. Multiple isoforms of TKS5 exist due to alternative mRNA splicing and promoter usage. 2018-06-25T14:16:43Z 2018-06-25T14:16:43Z 2017-10 2018-06-22T18:37:31Z Article http://purl.org/eprint/type/JournalArticle 1768-3262 http://hdl.handle.net/1721.1/116550 Li, Carman Man-Chung and Tyler Jacks. “SH3PXD2A (SH3 and PX Domains 2A).” Atlas of Genetics and Cytogenetics in Oncology and Haematology 6 (2016): 326-330 © 2016 Atlas of Genetics and Cytogenetics in Oncology and Haematology https://orcid.org/0000-0001-5785-8911 http://dx.doi.org/10.4267/2042/62941 Atlas of Genetics and Cytogenetics in Oncology and Haematology Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 http://creativecommons.org/licenses/by-nc-nd/2.0/ application/pdf INIST-CNRS Atlas of Genetics and Cytogenetics in Oncology and Haematology |
| spellingShingle | Li, Carman Man Chung Jacks, Tyler E. SH3PXD2A (SH3 and PX domains 2A) |
| title | SH3PXD2A (SH3 and PX domains 2A) |
| title_full | SH3PXD2A (SH3 and PX domains 2A) |
| title_fullStr | SH3PXD2A (SH3 and PX domains 2A) |
| title_full_unstemmed | SH3PXD2A (SH3 and PX domains 2A) |
| title_short | SH3PXD2A (SH3 and PX domains 2A) |
| title_sort | sh3pxd2a sh3 and px domains 2a |
| url | http://hdl.handle.net/1721.1/116550 https://orcid.org/0000-0001-5785-8911 |
| work_keys_str_mv | AT licarmanmanchung sh3pxd2ash3andpxdomains2a AT jackstylere sh3pxd2ash3andpxdomains2a |