Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation
Naive human embryonic stem cells (hESCs) can be derived from primed hESCs or directly from blastocysts, but their X chromosome state has remained unresolved. Here, we show that the inactive X chromosome (Xi) of primed hESCs was reactivated in naive culture conditions. Like cells of the blastocyst, t...
| Main Authors: | , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Published: |
Elsevier
2018
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| Online Access: | http://hdl.handle.net/1721.1/116596 |