Induced Pluripotent Stem Cells Meet Genome Editing
It is extremely rare for a single experiment to be so impactful and timely that it shapes and forecasts the experiments of the next decade. Here, we review how two such experiments - the generation of human induced pluripotent stem cells (iPSCs) and the development of CRISPR/Cas9 technology - have f...
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| Format: | Article |
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Elsevier
2018
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| Online Access: | http://hdl.handle.net/1721.1/116609 |
| _version_ | 1826190605811712000 |
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| author | Hockemeyer, Dirk Jaenisch, Rudolf |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Hockemeyer, Dirk Jaenisch, Rudolf |
| author_sort | Hockemeyer, Dirk |
| collection | MIT |
| description | It is extremely rare for a single experiment to be so impactful and timely that it shapes and forecasts the experiments of the next decade. Here, we review how two such experiments - the generation of human induced pluripotent stem cells (iPSCs) and the development of CRISPR/Cas9 technology - have fundamentally reshaped our approach to biomedical research, stem cell biology, and human genetics. We will also highlight the previous knowledge that iPSC and CRISPR/Cas9 technologies were built on as this groundwork demonstrated the need for solutions and the benefits that these technologies provided and set the stage for their success. |
| first_indexed | 2024-09-23T08:42:35Z |
| format | Article |
| id | mit-1721.1/116609 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T08:42:35Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1166092022-09-23T14:03:20Z Induced Pluripotent Stem Cells Meet Genome Editing Hockemeyer, Dirk Jaenisch, Rudolf Massachusetts Institute of Technology. Department of Biology Jaenisch, Rudolf It is extremely rare for a single experiment to be so impactful and timely that it shapes and forecasts the experiments of the next decade. Here, we review how two such experiments - the generation of human induced pluripotent stem cells (iPSCs) and the development of CRISPR/Cas9 technology - have fundamentally reshaped our approach to biomedical research, stem cell biology, and human genetics. We will also highlight the previous knowledge that iPSC and CRISPR/Cas9 technologies were built on as this groundwork demonstrated the need for solutions and the benefits that these technologies provided and set the stage for their success. National Institutes of Health (U.S.) (Grant 1R01NS088538-01) National Institutes of Health (U.S.) (Grant 2R01MH104610-15) 2018-06-26T14:20:10Z 2018-06-26T14:20:10Z 2016-05 2018-06-26T13:03:46Z Article http://purl.org/eprint/type/JournalArticle 1934-5909 http://hdl.handle.net/1721.1/116609 Hockemeyer, Dirk, and Rudolf Jaenisch. “Induced Pluripotent Stem Cells Meet Genome Editing.” Cell Stem Cell 18, 5 (May 2016): 573–586 © 2016 Elsevier Inc http://dx.doi.org/10.1016/J.STEM.2016.04.013 Cell Stem Cell Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Hockemeyer, Dirk Jaenisch, Rudolf Induced Pluripotent Stem Cells Meet Genome Editing |
| title | Induced Pluripotent Stem Cells Meet Genome Editing |
| title_full | Induced Pluripotent Stem Cells Meet Genome Editing |
| title_fullStr | Induced Pluripotent Stem Cells Meet Genome Editing |
| title_full_unstemmed | Induced Pluripotent Stem Cells Meet Genome Editing |
| title_short | Induced Pluripotent Stem Cells Meet Genome Editing |
| title_sort | induced pluripotent stem cells meet genome editing |
| url | http://hdl.handle.net/1721.1/116609 |
| work_keys_str_mv | AT hockemeyerdirk inducedpluripotentstemcellsmeetgenomeediting AT jaenischrudolf inducedpluripotentstemcellsmeetgenomeediting |