Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma
We report a comprehensive molecular characterization of pheochromocytomas and paragangliomas (PCCs/PGLs), a rare tumor type. Multi-platform integration revealed that PCCs/PGLs are driven by diverse alterations affecting multiple genes and pathways. Pathogenic germline mutations occurred in eight PCC...
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| Format: | Article |
| Published: |
Elsevier
2018
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| Online Access: | http://hdl.handle.net/1721.1/116699 |
| _version_ | 1826196699663564800 |
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| author | Fishbein, Lauren Walter, Vonn Danilova, Ludmila Robertson, A. Gordon Johnson, Amy R. Lichtenberg, Tara M. Murray, Bradley A. Ghayee, Hans K. Else, Tobias Ling, Shiyun Jefferys, Stuart R. de Cubas, Aguirre A. Wenz, Brandon Korpershoek, Esther Amelio, Antonio L. Makowski, Liza Rathmell, W. Kimryn Gimenez-Roqueplo, Anne-Paule Giordano, Thomas J. Asa, Sylvia L. Tischler, Arthur S. Pacak, Karel Nathanson, Katherine L. Wilkerson, Matthew D. Akbani, Rehan Ally, Adrian Amar, Laurence Amelio, Antonio L. Arachchi, Harindra Asa, Sylvia L. Auchus, Richard J. Auman, J. Todd Baertsch, Robert Balasundaram, Miruna Balu, Saianand Bartsch, Detlef K. Baudin, Eric Bauer, Thomas Beaver, Allison Benz, Christopher Beroukhim, Rameen Beuschlein, Felix Bodenheimer, Tom Boice, Lori Bowlby, Reanne Brooks, Denise Carlsen, Rebecca Carter, Suzie Cassol, Clarissa A. Cherniack, Andrew D. Chin, Lynda Cho, Juok Chuah, Eric Chudamani, Sudha Cope, Leslie Crain, Daniel Curley, Erin Danilova, Ludmila de Cubas, Aguirre A. de Krijger, Ronald R. Demchok, John A. Deutschbein, Timo Dhalla, Noreen Dimmock, David Dinjens, Winand N.M. Else, Tobias Eng, Charis Eschbacher, Jennifer Fassnacht, Martin Felau, Ina Feldman, Michael Ferguson, Martin L. Fiddes, Ian Fishbein, Lauren Frazer, Scott Gabriel, Stacey B. Gardner, Johanna Gastier-Foster, Julie M. Gehlenborg, Nils Gerken, Mark Getz, Gad Geurts, Jennifer Ghayee, Hans K. Gimenez-Roqueplo, Anne-Paule Giordano, Thomas J. Goldman, Mary Graim, Kiley Gupta, Manaswi Haan, David Hahner, Stefanie Hantel, Constanze Haussler, David Hayes, D. Neil Heiman, David I. Hoadley, Katherine A. Holt, Robert A. Hoyle, Alan P. Huang, Mei Hunt, Bryan Hutter, Carolyn M. Jefferys, Stuart R. Johnson, Amy R. Jones, Steven J.M. Jones, Corbin D. Kasaian, Katayoon Kebebew, Electron Kim, Jaegil Kimes, Patrick Knijnenburg, Theo Korpershoek, Esther Lander, Eric Lawrence, Michael S. Lechan, Ronald Lee, Darlene Leraas, Kristen M. Lerario, Antonio Lichtenberg, Tara M. Lin, Pei Ling, Shiyun Liu, Jia LiVolsi, Virginia A. Lolla, Laxmi Lotan, Yair Lu, Yiling Ma, Yussanne Maison, Nicole Makowski, Liza Mallery, David Mannelli, Massimo Marquard, Jessica Marra, Marco A. Matthew, Thomas Mayo, Michael Méatchi, Tchao Meng, Shaowu Merino, Maria J. Mete, Ozgur Meyerson, Matthew Mieczkowski, Piotr A. Mills, Gordon B. Moore, Richard A. Morozova, Olena Morris, Scott Mose, Lisle E. Mungall, Andrew J. Murray, Bradley A. Naresh, Rashi Nathanson, Katherine L. Newton, Yulia Ng, Sam Ni, Ying Noble, Michael S. Nwariaku, Fiemu Pacak, Karel Parker, Joel S. Paul, Evan Penny, Robert Perou, Charles M. Perou, Amy H. Pihl, Todd Powers, James Rabaglia, Jennifer Radenbaugh, Amie Ramirez, Nilsa C. Rao, Arjun Rathmell, W. Kimryn Riester, Anna Roach, Jeffrey Robertson, A. Gordon Sadeghi, Sara Saksena, Gordon Salama, Sofie Saller, Charles Sandusky, George Sbiera, Silviu Schein, Jacqueline E. Schumacher, Steven E. Shelton, Candace Shelton, Troy Sheth, Margi Shi, Yan Shih, Juliann Shmulevich, Ilya Simons, Janae V. Sipahimalani, Payal Skelly, Tara Sofia, Heidi J. Sokolov, Artem Soloway, Matthew G. Sougnez, Carrie Stuart, Josh Sun, Charlie Swatloski, Teresa Tam, Angela Tan, Donghui Tarnuzzer, Roy Tarvin, Katherine Thiessen, Nina Thorne, Leigh B. Timmers, Henri J. Tischler, Arthur S. Tse, Kane Uzunangelov, Vlado van Berkel, Anouk Veluvolu, Umadevi Vicha, Ales Voet, Doug Waldmann, Jens Walter, Vonn Wan, Yunhu Wang, Zhining Wang, Tracy S. Weaver, Joellen Weinstein, John N. Weismann, Dirk Wenz, Brandon Wilkerson, Matthew D. Wise, Lisa Wong, Tina Wu, Ye Yang, Liming Zelinka, Tomas Zenklusen, Jean C. Zhang, Jiashan (Julia) Zhang, Wei Zhu, Jingchun Zinzindohoué, Franck Zmuda, Erik Leshchiner, Ignaty Lander, Eric Steven Wong, Christopher, M. Eng. Massachusetts Institute of Technology |
| author2 | Broad Institute of MIT and Harvard |
| author_facet | Broad Institute of MIT and Harvard Fishbein, Lauren Walter, Vonn Danilova, Ludmila Robertson, A. Gordon Johnson, Amy R. Lichtenberg, Tara M. Murray, Bradley A. Ghayee, Hans K. Else, Tobias Ling, Shiyun Jefferys, Stuart R. de Cubas, Aguirre A. Wenz, Brandon Korpershoek, Esther Amelio, Antonio L. Makowski, Liza Rathmell, W. Kimryn Gimenez-Roqueplo, Anne-Paule Giordano, Thomas J. Asa, Sylvia L. Tischler, Arthur S. Pacak, Karel Nathanson, Katherine L. Wilkerson, Matthew D. Akbani, Rehan Ally, Adrian Amar, Laurence Amelio, Antonio L. Arachchi, Harindra Asa, Sylvia L. Auchus, Richard J. Auman, J. Todd Baertsch, Robert Balasundaram, Miruna Balu, Saianand Bartsch, Detlef K. Baudin, Eric Bauer, Thomas Beaver, Allison Benz, Christopher Beroukhim, Rameen Beuschlein, Felix Bodenheimer, Tom Boice, Lori Bowlby, Reanne Brooks, Denise Carlsen, Rebecca Carter, Suzie Cassol, Clarissa A. Cherniack, Andrew D. Chin, Lynda Cho, Juok Chuah, Eric Chudamani, Sudha Cope, Leslie Crain, Daniel Curley, Erin Danilova, Ludmila de Cubas, Aguirre A. de Krijger, Ronald R. Demchok, John A. Deutschbein, Timo Dhalla, Noreen Dimmock, David Dinjens, Winand N.M. Else, Tobias Eng, Charis Eschbacher, Jennifer Fassnacht, Martin Felau, Ina Feldman, Michael Ferguson, Martin L. Fiddes, Ian Fishbein, Lauren Frazer, Scott Gabriel, Stacey B. Gardner, Johanna Gastier-Foster, Julie M. Gehlenborg, Nils Gerken, Mark Getz, Gad Geurts, Jennifer Ghayee, Hans K. Gimenez-Roqueplo, Anne-Paule Giordano, Thomas J. Goldman, Mary Graim, Kiley Gupta, Manaswi Haan, David Hahner, Stefanie Hantel, Constanze Haussler, David Hayes, D. Neil Heiman, David I. Hoadley, Katherine A. Holt, Robert A. Hoyle, Alan P. Huang, Mei Hunt, Bryan Hutter, Carolyn M. Jefferys, Stuart R. Johnson, Amy R. Jones, Steven J.M. Jones, Corbin D. Kasaian, Katayoon Kebebew, Electron Kim, Jaegil Kimes, Patrick Knijnenburg, Theo Korpershoek, Esther Lander, Eric Lawrence, Michael S. Lechan, Ronald Lee, Darlene Leraas, Kristen M. Lerario, Antonio Lichtenberg, Tara M. Lin, Pei Ling, Shiyun Liu, Jia LiVolsi, Virginia A. Lolla, Laxmi Lotan, Yair Lu, Yiling Ma, Yussanne Maison, Nicole Makowski, Liza Mallery, David Mannelli, Massimo Marquard, Jessica Marra, Marco A. Matthew, Thomas Mayo, Michael Méatchi, Tchao Meng, Shaowu Merino, Maria J. Mete, Ozgur Meyerson, Matthew Mieczkowski, Piotr A. Mills, Gordon B. Moore, Richard A. Morozova, Olena Morris, Scott Mose, Lisle E. Mungall, Andrew J. Murray, Bradley A. Naresh, Rashi Nathanson, Katherine L. Newton, Yulia Ng, Sam Ni, Ying Noble, Michael S. Nwariaku, Fiemu Pacak, Karel Parker, Joel S. Paul, Evan Penny, Robert Perou, Charles M. Perou, Amy H. Pihl, Todd Powers, James Rabaglia, Jennifer Radenbaugh, Amie Ramirez, Nilsa C. Rao, Arjun Rathmell, W. Kimryn Riester, Anna Roach, Jeffrey Robertson, A. Gordon Sadeghi, Sara Saksena, Gordon Salama, Sofie Saller, Charles Sandusky, George Sbiera, Silviu Schein, Jacqueline E. Schumacher, Steven E. Shelton, Candace Shelton, Troy Sheth, Margi Shi, Yan Shih, Juliann Shmulevich, Ilya Simons, Janae V. Sipahimalani, Payal Skelly, Tara Sofia, Heidi J. Sokolov, Artem Soloway, Matthew G. Sougnez, Carrie Stuart, Josh Sun, Charlie Swatloski, Teresa Tam, Angela Tan, Donghui Tarnuzzer, Roy Tarvin, Katherine Thiessen, Nina Thorne, Leigh B. Timmers, Henri J. Tischler, Arthur S. Tse, Kane Uzunangelov, Vlado van Berkel, Anouk Veluvolu, Umadevi Vicha, Ales Voet, Doug Waldmann, Jens Walter, Vonn Wan, Yunhu Wang, Zhining Wang, Tracy S. Weaver, Joellen Weinstein, John N. Weismann, Dirk Wenz, Brandon Wilkerson, Matthew D. Wise, Lisa Wong, Tina Wu, Ye Yang, Liming Zelinka, Tomas Zenklusen, Jean C. Zhang, Jiashan (Julia) Zhang, Wei Zhu, Jingchun Zinzindohoué, Franck Zmuda, Erik Leshchiner, Ignaty Lander, Eric Steven Wong, Christopher, M. Eng. Massachusetts Institute of Technology |
| author_sort | Fishbein, Lauren |
| collection | MIT |
| description | We report a comprehensive molecular characterization of pheochromocytomas and paragangliomas (PCCs/PGLs), a rare tumor type. Multi-platform integration revealed that PCCs/PGLs are driven by diverse alterations affecting multiple genes and pathways. Pathogenic germline mutations occurred in eight PCC/PGL susceptibility genes. We identified CSDE1 as a somatically mutated driver gene, complementing four known drivers (HRAS, RET, EPAS1, and NF1). We also discovered fusion genes in PCCs/PGLs, involving MAML3, BRAF, NGFR, and NF1. Integrated analysis classified PCCs/PGLs into four molecularly defined groups: a kinase signaling subtype, a pseudohypoxia subtype, a Wnt-altered subtype, driven by MAML3 and CSDE1, and a cortical admixture subtype. Correlates of metastatic PCCs/PGLs included the MAML3 fusion gene. This integrated molecular characterization provides a comprehensive foundation for developing PCC/PGL precision medicine. |
| first_indexed | 2024-09-23T10:35:26Z |
| format | Article |
| id | mit-1721.1/116699 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T10:35:26Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1166992022-09-27T10:01:52Z Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma Fishbein, Lauren Walter, Vonn Danilova, Ludmila Robertson, A. Gordon Johnson, Amy R. Lichtenberg, Tara M. Murray, Bradley A. Ghayee, Hans K. Else, Tobias Ling, Shiyun Jefferys, Stuart R. de Cubas, Aguirre A. Wenz, Brandon Korpershoek, Esther Amelio, Antonio L. Makowski, Liza Rathmell, W. Kimryn Gimenez-Roqueplo, Anne-Paule Giordano, Thomas J. Asa, Sylvia L. Tischler, Arthur S. Pacak, Karel Nathanson, Katherine L. Wilkerson, Matthew D. Akbani, Rehan Ally, Adrian Amar, Laurence Amelio, Antonio L. Arachchi, Harindra Asa, Sylvia L. Auchus, Richard J. Auman, J. Todd Baertsch, Robert Balasundaram, Miruna Balu, Saianand Bartsch, Detlef K. Baudin, Eric Bauer, Thomas Beaver, Allison Benz, Christopher Beroukhim, Rameen Beuschlein, Felix Bodenheimer, Tom Boice, Lori Bowlby, Reanne Brooks, Denise Carlsen, Rebecca Carter, Suzie Cassol, Clarissa A. Cherniack, Andrew D. Chin, Lynda Cho, Juok Chuah, Eric Chudamani, Sudha Cope, Leslie Crain, Daniel Curley, Erin Danilova, Ludmila de Cubas, Aguirre A. de Krijger, Ronald R. Demchok, John A. Deutschbein, Timo Dhalla, Noreen Dimmock, David Dinjens, Winand N.M. Else, Tobias Eng, Charis Eschbacher, Jennifer Fassnacht, Martin Felau, Ina Feldman, Michael Ferguson, Martin L. Fiddes, Ian Fishbein, Lauren Frazer, Scott Gabriel, Stacey B. Gardner, Johanna Gastier-Foster, Julie M. Gehlenborg, Nils Gerken, Mark Getz, Gad Geurts, Jennifer Ghayee, Hans K. Gimenez-Roqueplo, Anne-Paule Giordano, Thomas J. Goldman, Mary Graim, Kiley Gupta, Manaswi Haan, David Hahner, Stefanie Hantel, Constanze Haussler, David Hayes, D. Neil Heiman, David I. Hoadley, Katherine A. Holt, Robert A. Hoyle, Alan P. Huang, Mei Hunt, Bryan Hutter, Carolyn M. Jefferys, Stuart R. Johnson, Amy R. Jones, Steven J.M. Jones, Corbin D. Kasaian, Katayoon Kebebew, Electron Kim, Jaegil Kimes, Patrick Knijnenburg, Theo Korpershoek, Esther Lander, Eric Lawrence, Michael S. Lechan, Ronald Lee, Darlene Leraas, Kristen M. Lerario, Antonio Lichtenberg, Tara M. Lin, Pei Ling, Shiyun Liu, Jia LiVolsi, Virginia A. Lolla, Laxmi Lotan, Yair Lu, Yiling Ma, Yussanne Maison, Nicole Makowski, Liza Mallery, David Mannelli, Massimo Marquard, Jessica Marra, Marco A. Matthew, Thomas Mayo, Michael Méatchi, Tchao Meng, Shaowu Merino, Maria J. Mete, Ozgur Meyerson, Matthew Mieczkowski, Piotr A. Mills, Gordon B. Moore, Richard A. Morozova, Olena Morris, Scott Mose, Lisle E. Mungall, Andrew J. Murray, Bradley A. Naresh, Rashi Nathanson, Katherine L. Newton, Yulia Ng, Sam Ni, Ying Noble, Michael S. Nwariaku, Fiemu Pacak, Karel Parker, Joel S. Paul, Evan Penny, Robert Perou, Charles M. Perou, Amy H. Pihl, Todd Powers, James Rabaglia, Jennifer Radenbaugh, Amie Ramirez, Nilsa C. Rao, Arjun Rathmell, W. Kimryn Riester, Anna Roach, Jeffrey Robertson, A. Gordon Sadeghi, Sara Saksena, Gordon Salama, Sofie Saller, Charles Sandusky, George Sbiera, Silviu Schein, Jacqueline E. Schumacher, Steven E. Shelton, Candace Shelton, Troy Sheth, Margi Shi, Yan Shih, Juliann Shmulevich, Ilya Simons, Janae V. Sipahimalani, Payal Skelly, Tara Sofia, Heidi J. Sokolov, Artem Soloway, Matthew G. Sougnez, Carrie Stuart, Josh Sun, Charlie Swatloski, Teresa Tam, Angela Tan, Donghui Tarnuzzer, Roy Tarvin, Katherine Thiessen, Nina Thorne, Leigh B. Timmers, Henri J. Tischler, Arthur S. Tse, Kane Uzunangelov, Vlado van Berkel, Anouk Veluvolu, Umadevi Vicha, Ales Voet, Doug Waldmann, Jens Walter, Vonn Wan, Yunhu Wang, Zhining Wang, Tracy S. Weaver, Joellen Weinstein, John N. Weismann, Dirk Wenz, Brandon Wilkerson, Matthew D. Wise, Lisa Wong, Tina Wu, Ye Yang, Liming Zelinka, Tomas Zenklusen, Jean C. Zhang, Jiashan (Julia) Zhang, Wei Zhu, Jingchun Zinzindohoué, Franck Zmuda, Erik Leshchiner, Ignaty Lander, Eric Steven Wong, Christopher, M. Eng. Massachusetts Institute of Technology Broad Institute of MIT and Harvard Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Chemical Engineering Leshchiner, Ignaty Lander, Eric Steven We report a comprehensive molecular characterization of pheochromocytomas and paragangliomas (PCCs/PGLs), a rare tumor type. Multi-platform integration revealed that PCCs/PGLs are driven by diverse alterations affecting multiple genes and pathways. Pathogenic germline mutations occurred in eight PCC/PGL susceptibility genes. We identified CSDE1 as a somatically mutated driver gene, complementing four known drivers (HRAS, RET, EPAS1, and NF1). We also discovered fusion genes in PCCs/PGLs, involving MAML3, BRAF, NGFR, and NF1. Integrated analysis classified PCCs/PGLs into four molecularly defined groups: a kinase signaling subtype, a pseudohypoxia subtype, a Wnt-altered subtype, driven by MAML3 and CSDE1, and a cortical admixture subtype. Correlates of metastatic PCCs/PGLs included the MAML3 fusion gene. This integrated molecular characterization provides a comprehensive foundation for developing PCC/PGL precision medicine. National Institutes of Health (U.S.) (Grant U54HG003273) National Institutes of Health (U.S.) (Grant U54HG003067) National Institutes of Health (U.S.) (Grant U54HG003079) National Institutes of Health (U.S.) (Grant U24CA143799) National Institutes of Health (U.S.) (Grant U24CA143835) National Institutes of Health (U.S.) (Grant U24CA143840) National Institutes of Health (U.S.) (Grant U24CA143843) National Institutes of Health (U.S.) (Grant U24CA143845) National Institutes of Health (U.S.) (Grant U24CA143848) National Institutes of Health (U.S.) (Grant U24CA143858) National Institutes of Health (U.S.) (Grant U24CA143866) National Institutes of Health (U.S.) (Grant U24CA143867) National Institutes of Health (U.S.) (Grant U24CA143882) National Institutes of Health (U.S.) (Grant U24CA143883) National Institutes of Health (U.S.) (Grant U24CA144025) National Institutes of Health (U.S.) (Grant P30CA016672) 2018-06-29T18:33:12Z 2018-06-29T18:33:12Z 2017-02 2016-10 2018-06-28T13:50:37Z Article http://purl.org/eprint/type/JournalArticle 1535-6108 http://hdl.handle.net/1721.1/116699 Fishbein, Lauren et al. “Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma.” Cancer Cell 31, 2 (February 2017): 181–193 © 2017 Elsevier Inc http://dx.doi.org/10.1016/J.CCELL.2017.01.001 Cancer Cell Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Fishbein, Lauren Walter, Vonn Danilova, Ludmila Robertson, A. Gordon Johnson, Amy R. Lichtenberg, Tara M. Murray, Bradley A. Ghayee, Hans K. Else, Tobias Ling, Shiyun Jefferys, Stuart R. de Cubas, Aguirre A. Wenz, Brandon Korpershoek, Esther Amelio, Antonio L. Makowski, Liza Rathmell, W. Kimryn Gimenez-Roqueplo, Anne-Paule Giordano, Thomas J. Asa, Sylvia L. Tischler, Arthur S. Pacak, Karel Nathanson, Katherine L. Wilkerson, Matthew D. Akbani, Rehan Ally, Adrian Amar, Laurence Amelio, Antonio L. Arachchi, Harindra Asa, Sylvia L. Auchus, Richard J. Auman, J. Todd Baertsch, Robert Balasundaram, Miruna Balu, Saianand Bartsch, Detlef K. Baudin, Eric Bauer, Thomas Beaver, Allison Benz, Christopher Beroukhim, Rameen Beuschlein, Felix Bodenheimer, Tom Boice, Lori Bowlby, Reanne Brooks, Denise Carlsen, Rebecca Carter, Suzie Cassol, Clarissa A. Cherniack, Andrew D. Chin, Lynda Cho, Juok Chuah, Eric Chudamani, Sudha Cope, Leslie Crain, Daniel Curley, Erin Danilova, Ludmila de Cubas, Aguirre A. de Krijger, Ronald R. Demchok, John A. Deutschbein, Timo Dhalla, Noreen Dimmock, David Dinjens, Winand N.M. Else, Tobias Eng, Charis Eschbacher, Jennifer Fassnacht, Martin Felau, Ina Feldman, Michael Ferguson, Martin L. Fiddes, Ian Fishbein, Lauren Frazer, Scott Gabriel, Stacey B. Gardner, Johanna Gastier-Foster, Julie M. Gehlenborg, Nils Gerken, Mark Getz, Gad Geurts, Jennifer Ghayee, Hans K. Gimenez-Roqueplo, Anne-Paule Giordano, Thomas J. Goldman, Mary Graim, Kiley Gupta, Manaswi Haan, David Hahner, Stefanie Hantel, Constanze Haussler, David Hayes, D. Neil Heiman, David I. Hoadley, Katherine A. Holt, Robert A. Hoyle, Alan P. Huang, Mei Hunt, Bryan Hutter, Carolyn M. Jefferys, Stuart R. Johnson, Amy R. Jones, Steven J.M. Jones, Corbin D. Kasaian, Katayoon Kebebew, Electron Kim, Jaegil Kimes, Patrick Knijnenburg, Theo Korpershoek, Esther Lander, Eric Lawrence, Michael S. Lechan, Ronald Lee, Darlene Leraas, Kristen M. Lerario, Antonio Lichtenberg, Tara M. Lin, Pei Ling, Shiyun Liu, Jia LiVolsi, Virginia A. Lolla, Laxmi Lotan, Yair Lu, Yiling Ma, Yussanne Maison, Nicole Makowski, Liza Mallery, David Mannelli, Massimo Marquard, Jessica Marra, Marco A. Matthew, Thomas Mayo, Michael Méatchi, Tchao Meng, Shaowu Merino, Maria J. Mete, Ozgur Meyerson, Matthew Mieczkowski, Piotr A. Mills, Gordon B. Moore, Richard A. Morozova, Olena Morris, Scott Mose, Lisle E. Mungall, Andrew J. Murray, Bradley A. Naresh, Rashi Nathanson, Katherine L. Newton, Yulia Ng, Sam Ni, Ying Noble, Michael S. Nwariaku, Fiemu Pacak, Karel Parker, Joel S. Paul, Evan Penny, Robert Perou, Charles M. Perou, Amy H. Pihl, Todd Powers, James Rabaglia, Jennifer Radenbaugh, Amie Ramirez, Nilsa C. Rao, Arjun Rathmell, W. Kimryn Riester, Anna Roach, Jeffrey Robertson, A. Gordon Sadeghi, Sara Saksena, Gordon Salama, Sofie Saller, Charles Sandusky, George Sbiera, Silviu Schein, Jacqueline E. Schumacher, Steven E. Shelton, Candace Shelton, Troy Sheth, Margi Shi, Yan Shih, Juliann Shmulevich, Ilya Simons, Janae V. Sipahimalani, Payal Skelly, Tara Sofia, Heidi J. Sokolov, Artem Soloway, Matthew G. Sougnez, Carrie Stuart, Josh Sun, Charlie Swatloski, Teresa Tam, Angela Tan, Donghui Tarnuzzer, Roy Tarvin, Katherine Thiessen, Nina Thorne, Leigh B. Timmers, Henri J. Tischler, Arthur S. Tse, Kane Uzunangelov, Vlado van Berkel, Anouk Veluvolu, Umadevi Vicha, Ales Voet, Doug Waldmann, Jens Walter, Vonn Wan, Yunhu Wang, Zhining Wang, Tracy S. Weaver, Joellen Weinstein, John N. Weismann, Dirk Wenz, Brandon Wilkerson, Matthew D. Wise, Lisa Wong, Tina Wu, Ye Yang, Liming Zelinka, Tomas Zenklusen, Jean C. Zhang, Jiashan (Julia) Zhang, Wei Zhu, Jingchun Zinzindohoué, Franck Zmuda, Erik Leshchiner, Ignaty Lander, Eric Steven Wong, Christopher, M. Eng. Massachusetts Institute of Technology Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma |
| title | Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma |
| title_full | Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma |
| title_fullStr | Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma |
| title_full_unstemmed | Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma |
| title_short | Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma |
| title_sort | comprehensive molecular characterization of pheochromocytoma and paraganglioma |
| url | http://hdl.handle.net/1721.1/116699 |
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wongchristophermengmassachusettsinstituteoftechnology comprehensivemolecularcharacterizationofpheochromocytomaandparaganglioma |