Activating embryonic development in Drosophila
The transition from oocyte to embryo marks the onset of development. This process requires complex regulation to link developmental signals with profound changes in mRNA translation, cell cycle control, and metabolism. This control is beginning to be understood for most organisms, and research in th...
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| Format: | Article |
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Elsevier BV
2018
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| Online Access: | http://hdl.handle.net/1721.1/116724 https://orcid.org/0000-0003-3994-9195 https://orcid.org/0000-0002-7934-111X |
| _version_ | 1826207173168857088 |
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| author | Aviles Pagan, Emir Enrique Orr-Weaver, Terry |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Aviles Pagan, Emir Enrique Orr-Weaver, Terry |
| author_sort | Aviles Pagan, Emir Enrique |
| collection | MIT |
| description | The transition from oocyte to embryo marks the onset of development. This process requires complex regulation to link developmental signals with profound changes in mRNA translation, cell cycle control, and metabolism. This control is beginning to be understood for most organisms, and research in the fruit fly Drosophila melanogaster has generated new insights. Recent findings have increased our understanding of the roles played by hormone and Ca2+signaling events as well as metabolic remodeling crucial for this transition. Specialized features of the structure and assembly of the meiotic spindle have been identified. The changes in protein levels, mRNA translation, and polyadenylation that occur as the oocyte becomes an embryo have been identified together with key aspects of their regulation. Here we highlight these important developments and the insights they provide on the intricate regulation of this dramatic transition. |
| first_indexed | 2024-09-23T13:45:12Z |
| format | Article |
| id | mit-1721.1/116724 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T13:45:12Z |
| publishDate | 2018 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1167242022-09-28T15:56:49Z Activating embryonic development in Drosophila Aviles Pagan, Emir Enrique Orr-Weaver, Terry Massachusetts Institute of Technology. Department of Biology Aviles Pagan, Emir Enrique Orr-Weaver, Terry The transition from oocyte to embryo marks the onset of development. This process requires complex regulation to link developmental signals with profound changes in mRNA translation, cell cycle control, and metabolism. This control is beginning to be understood for most organisms, and research in the fruit fly Drosophila melanogaster has generated new insights. Recent findings have increased our understanding of the roles played by hormone and Ca2+signaling events as well as metabolic remodeling crucial for this transition. Specialized features of the structure and assembly of the meiotic spindle have been identified. The changes in protein levels, mRNA translation, and polyadenylation that occur as the oocyte becomes an embryo have been identified together with key aspects of their regulation. Here we highlight these important developments and the insights they provide on the intricate regulation of this dramatic transition. National Institutes of Health (U.S.) (grant GM118098) 2018-07-02T17:57:52Z 2018-07-02T17:57:52Z 2018-02 2017-12 2018-06-29T19:40:21Z Article http://purl.org/eprint/type/JournalArticle 10849521 http://hdl.handle.net/1721.1/116724 Avilés-Pagán, Emir E., and Terry L. Orr-Weaver. “Activating Embryonic Development in Drosophila.” Seminars in Cell & Developmental Biology (February 2018). https://orcid.org/0000-0003-3994-9195 https://orcid.org/0000-0002-7934-111X http://dx.doi.org/10.1016/J.SEMCDB.2018.02.019 Seminars in Cell & Developmental Biology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV Elsevier |
| spellingShingle | Aviles Pagan, Emir Enrique Orr-Weaver, Terry Activating embryonic development in Drosophila |
| title | Activating embryonic development in Drosophila |
| title_full | Activating embryonic development in Drosophila |
| title_fullStr | Activating embryonic development in Drosophila |
| title_full_unstemmed | Activating embryonic development in Drosophila |
| title_short | Activating embryonic development in Drosophila |
| title_sort | activating embryonic development in drosophila |
| url | http://hdl.handle.net/1721.1/116724 https://orcid.org/0000-0003-3994-9195 https://orcid.org/0000-0002-7934-111X |
| work_keys_str_mv | AT avilespaganemirenrique activatingembryonicdevelopmentindrosophila AT orrweaverterry activatingembryonicdevelopmentindrosophila |