Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay

Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay

Although studies have identified hundreds of loci associated with human traits and diseases, pinpointing causal alleles remains difficult, particularly for non-coding variants. To address this challenge, we adapted the massively parallel reporter assay (MPRA) to identify variants that directly modul...

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Bibliographic Details
Main Authors: Park, Daniel S., Liu, Brandon, Winnicki, Sarah, Reilly, Steven K., Andersen, Kristian G., Tewhey, Ryan, Kotliar, Dylan A., Andersen, Kristian, Mikkelsen, Tarjei, Lander, Eric Steven, Schaffner, Stephen F, Sabeti, Pardis
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Published: Elsevier 2018
Online Access:http://hdl.handle.net/1721.1/116742
https://orcid.org/0000-0002-7968-645X

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