A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells

A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells

Reversing the dysfunctional T cell state that arises in cancer and chronic viral infections is the focus of therapeutic interventions; however, current therapies are effective in only some patients and some tumor types. To gain a deeper molecular understanding of the dysfunctional T cell state, we a...

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Bibliographic Details
Main Authors: Singer, Meromit, Cong, Le, Kowalczyk, Monika S., Zhang, Huiyuan, Nyman, Jackson, Sakuishi, Kaori, Kurtulus, Sema, Gennert, David, Xia, Junrong, Kwon, John Y.H., Nevin, James, Herbst, Rebecca H., Yanai, Itai, Rozenblatt-Rosen, Orit, Kuchroo, Vijay K., Anderson, Ana C., Marjanovic, Nemanja, Regev, Aviv, Wang, Chao
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program
Format: Article
Published: Elsevier 2018
Online Access:http://hdl.handle.net/1721.1/116761
https://orcid.org/0000-0001-8567-2049

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