Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase

Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase

A complex interplay of environmental factors impacts the metabolism of human cells, but neither traditional culture media nor mouse plasma mimic the metabolite composition of human plasma. Here, we developed a culture medium with polar metabolite concentrations comparable to those of human plasma (h...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Cantor, Jason R., Abu-Remaileh, Monther, Kanarek, Naama, Freinkman, Elizaveta, Gao, Xin, Louissaint, Abner, Lewis, Caroline A., Sabatini, David
Άλλοι συγγραφείς:	Massachusetts Institute of Technology. Department of Biology
Μορφή:	Άρθρο
Έκδοση:	Elsevier 2018
Διαθέσιμο Online:	http://hdl.handle.net/1721.1/116765 https://orcid.org/0000-0002-1446-7256

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