A CRISPR screen identifies a pathway required for paraquat-induced cell death

A CRISPR screen identifies a pathway required for paraquat-induced cell death

Paraquat, a herbicide linked to Parkinson's disease, generates reactive oxygen species (ROS), which causes cell death. Because the source of paraquat-induced ROS production remains unknown, we conducted a CRISPR-based positive-selection screen to identify metabolic genes essential for paraquat-...

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Bibliographic Details
Main Authors: Reczek, Colleen R, Birsoy, Kıvanç, Kong, Hyewon, Martínez-Reyes, Inmaculada, Gao, Peng, Chandel, Navdeep S, Wang, Tim, Sabatini, David
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Published: Nature Publishing Group 2018
Online Access:http://hdl.handle.net/1721.1/116772
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/116772
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0002-1446-7256

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