Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators
The human X and Y chromosomes evolved from an ordinary pair of autosomes, but millions of years ago genetic decay ravaged the Y chromosome, and only three per cent of its ancestral genes survived. We reconstructed the evolution of the Y chromosome across eight mammals to identify biases in gene cont...
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| Format: | Article |
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Springer Nature
2018
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| Online Access: | http://hdl.handle.net/1721.1/116789 https://orcid.org/0000-0001-9920-3411 |
| _version_ | 1826199243482726400 |
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| author | Hughes, Jennifer F. Skaletsky, Helen Brown, Laura G. Pyntikova, Tatyana Cho, Ting-Jan Koutseva, Natalia Zaghlul, Sara Graves, Tina Rock, Susie Kremitzki, Colin Fulton, Robert S. Dugan, Shannon Ding, Yan Morton, Donna Khan, Ziad Lewis, Lora Buhay, Christian Wang, Qiaoyan Watt, Jennifer Holder, Michael Lee, Sandy Nazareth, Lynne Alföldi, Jessica Rozen, Steve Muzny, Donna M. Warren, Wesley C. Gibbs, Richard A. Wilson, Richard K. Bellott, Daniel W. Page, David C |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Hughes, Jennifer F. Skaletsky, Helen Brown, Laura G. Pyntikova, Tatyana Cho, Ting-Jan Koutseva, Natalia Zaghlul, Sara Graves, Tina Rock, Susie Kremitzki, Colin Fulton, Robert S. Dugan, Shannon Ding, Yan Morton, Donna Khan, Ziad Lewis, Lora Buhay, Christian Wang, Qiaoyan Watt, Jennifer Holder, Michael Lee, Sandy Nazareth, Lynne Alföldi, Jessica Rozen, Steve Muzny, Donna M. Warren, Wesley C. Gibbs, Richard A. Wilson, Richard K. Bellott, Daniel W. Page, David C |
| author_sort | Hughes, Jennifer F. |
| collection | MIT |
| description | The human X and Y chromosomes evolved from an ordinary pair of autosomes, but millions of years ago genetic decay ravaged the Y chromosome, and only three per cent of its ancestral genes survived. We reconstructed the evolution of the Y chromosome across eight mammals to identify biases in gene content and the selective pressures that preserved the surviving ancestral genes. Our findings indicate that survival was nonrandom, and in two cases, convergent across placental and marsupial mammals. We conclude that the gene content of the Y chromosome became specialized through selection to maintain the ancestral dosage of homologous X-Y gene pairs that function as broadly expressed regulators of transcription, translation and protein stability. We propose that beyond its roles in testis determination and spermatogenesis, the Y chromosome is essential for male viability, and has unappreciated roles in Turner (tm) s syndrome and in phenotypic differences between the sexes in health and disease. |
| first_indexed | 2024-09-23T11:16:59Z |
| format | Article |
| id | mit-1721.1/116789 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T11:16:59Z |
| publishDate | 2018 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | mit-1721.1/1167892022-09-27T18:26:10Z Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators Hughes, Jennifer F. Skaletsky, Helen Brown, Laura G. Pyntikova, Tatyana Cho, Ting-Jan Koutseva, Natalia Zaghlul, Sara Graves, Tina Rock, Susie Kremitzki, Colin Fulton, Robert S. Dugan, Shannon Ding, Yan Morton, Donna Khan, Ziad Lewis, Lora Buhay, Christian Wang, Qiaoyan Watt, Jennifer Holder, Michael Lee, Sandy Nazareth, Lynne Alföldi, Jessica Rozen, Steve Muzny, Donna M. Warren, Wesley C. Gibbs, Richard A. Wilson, Richard K. Bellott, Daniel W. Page, David C Massachusetts Institute of Technology. Department of Biology Bellott, Daniel W. Page, David C The human X and Y chromosomes evolved from an ordinary pair of autosomes, but millions of years ago genetic decay ravaged the Y chromosome, and only three per cent of its ancestral genes survived. We reconstructed the evolution of the Y chromosome across eight mammals to identify biases in gene content and the selective pressures that preserved the surviving ancestral genes. Our findings indicate that survival was nonrandom, and in two cases, convergent across placental and marsupial mammals. We conclude that the gene content of the Y chromosome became specialized through selection to maintain the ancestral dosage of homologous X-Y gene pairs that function as broadly expressed regulators of transcription, translation and protein stability. We propose that beyond its roles in testis determination and spermatogenesis, the Y chromosome is essential for male viability, and has unappreciated roles in Turner (tm) s syndrome and in phenotypic differences between the sexes in health and disease. 2018-07-05T14:20:21Z 2018-07-05T14:20:21Z 2014-04 2013-11 2018-07-02T14:29:22Z Article http://purl.org/eprint/type/JournalArticle 0028-0836 1476-4687 http://hdl.handle.net/1721.1/116789 Bellott, Daniel W. et al. “Mammalian Y Chromosomes Retain Widely Expressed Dosage-Sensitive Regulators.” Nature 508, 7497 (April 2014): 494–499 © 2014 Macmillan Publishers Limited https://orcid.org/0000-0001-9920-3411 http://dx.doi.org/10.1038/NATURE13206 Nature Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Springer Nature PMC |
| spellingShingle | Hughes, Jennifer F. Skaletsky, Helen Brown, Laura G. Pyntikova, Tatyana Cho, Ting-Jan Koutseva, Natalia Zaghlul, Sara Graves, Tina Rock, Susie Kremitzki, Colin Fulton, Robert S. Dugan, Shannon Ding, Yan Morton, Donna Khan, Ziad Lewis, Lora Buhay, Christian Wang, Qiaoyan Watt, Jennifer Holder, Michael Lee, Sandy Nazareth, Lynne Alföldi, Jessica Rozen, Steve Muzny, Donna M. Warren, Wesley C. Gibbs, Richard A. Wilson, Richard K. Bellott, Daniel W. Page, David C Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators |
| title | Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators |
| title_full | Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators |
| title_fullStr | Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators |
| title_full_unstemmed | Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators |
| title_short | Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators |
| title_sort | mammalian y chromosomes retain widely expressed dosage sensitive regulators |
| url | http://hdl.handle.net/1721.1/116789 https://orcid.org/0000-0001-9920-3411 |
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