Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine
The AAA + Cdc48 ATPase (alias p97 or VCP) is a key player in multiple ubiquitin-dependent cell signaling, degradation, and quality control pathways. Central to these broad biological functions is the ability of Cdc48 to interact with a large number of adaptor proteins and to remodel macromolecular p...
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| Format: | Article |
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Elsevier
2018
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| Online Access: | http://hdl.handle.net/1721.1/116854 https://orcid.org/0000-0002-1719-5399 |
| _version_ | 1826210314097524736 |
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| author | Barthelme, Dominik Sauer, Robert T. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Barthelme, Dominik Sauer, Robert T. |
| author_sort | Barthelme, Dominik |
| collection | MIT |
| description | The AAA + Cdc48 ATPase (alias p97 or VCP) is a key player in multiple ubiquitin-dependent cell signaling, degradation, and quality control pathways. Central to these broad biological functions is the ability of Cdc48 to interact with a large number of adaptor proteins and to remodel macromolecular proteins and their complexes. Different models have been proposed to explain how Cdc48 might couple ATP hydrolysis to forcible unfolding, dissociation, or remodeling of cellular clients. In this review, we provide an overview of possible mechanisms for substrate unfolding/remodeling by this conserved and essential AAA + protein machine and their adaption and possible biological function throughout evolution. Keywords: AAA + machine; protein remodeling; human disease |
| first_indexed | 2024-09-23T14:47:51Z |
| format | Article |
| id | mit-1721.1/116854 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T14:47:51Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1168542022-10-01T22:33:00Z Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine Barthelme, Dominik Sauer, Robert T. Massachusetts Institute of Technology. Department of Biology Barthelme, Dominik Sauer, Robert T. The AAA + Cdc48 ATPase (alias p97 or VCP) is a key player in multiple ubiquitin-dependent cell signaling, degradation, and quality control pathways. Central to these broad biological functions is the ability of Cdc48 to interact with a large number of adaptor proteins and to remodel macromolecular proteins and their complexes. Different models have been proposed to explain how Cdc48 might couple ATP hydrolysis to forcible unfolding, dissociation, or remodeling of cellular clients. In this review, we provide an overview of possible mechanisms for substrate unfolding/remodeling by this conserved and essential AAA + protein machine and their adaption and possible biological function throughout evolution. Keywords: AAA + machine; protein remodeling; human disease National Institutes of Health (U.S.) (Grant AI-16892) 2018-07-09T14:39:42Z 2018-07-09T14:39:42Z 2015-12 2015-11 2018-07-09T12:52:52Z Article http://purl.org/eprint/type/JournalArticle 0022-2836 1089-8638 http://hdl.handle.net/1721.1/116854 Barthelme, Dominik and Robert T. Sauer. “Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine.” Journal of Molecular Biology 428, 9 (May 2016): 1861–1869 © 2015 Elsevier Ltd https://orcid.org/0000-0002-1719-5399 http://dx.doi.org/10.1016/J.JMB.2015.11.015 Journal of Molecular Biology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Barthelme, Dominik Sauer, Robert T. Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine |
| title | Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine |
| title_full | Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine |
| title_fullStr | Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine |
| title_full_unstemmed | Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine |
| title_short | Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine |
| title_sort | origin and functional evolution of the cdc48 p97 vcp aaa protein unfolding and remodeling machine |
| url | http://hdl.handle.net/1721.1/116854 https://orcid.org/0000-0002-1719-5399 |
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