Locus coeruleus input to hippocampal CA3 drives single-trial learning of a novel context
The memory for a new episode is formed immediately upon experience and can last up to a lifetime. It has been shown that the hippocampal network plays a fundamental role in the rapid acquisition of a memory of a one-time experience, in which the novelty component of the experience promotes the promp...
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| Format: | Article |
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National Academy of Sciences (U.S.)
2018
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| Online Access: | http://hdl.handle.net/1721.1/116867 https://orcid.org/0000-0003-1566-0063 https://orcid.org/0000-0002-2419-794X https://orcid.org/0000-0003-2839-8228 |
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| author | Abe, Kuniya Wagatsuma, Akiko Okuyama, Teruhiro Sun, Chen Smith, Lillian Tonegawa, Susumu |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Abe, Kuniya Wagatsuma, Akiko Okuyama, Teruhiro Sun, Chen Smith, Lillian Tonegawa, Susumu |
| author_sort | Abe, Kuniya |
| collection | MIT |
| description | The memory for a new episode is formed immediately upon experience and can last up to a lifetime. It has been shown that the hippocampal network plays a fundamental role in the rapid acquisition of a memory of a one-time experience, in which the novelty component of the experience promotes the prompt formation of the memory. However, it remains unclear which neural circuits convey the novelty signal to the hippocampus for the single-trial learning. Here, we show that during encoding neuromodulatory input from locus coeruleus (LC) to CA3, but not CA1 or to the dentate gyrus, is necessary to facilitate novel contextual learning. Silencing LC activity during exposure to a novel context reduced subsequent reactivation of the engram cell ensembles in CA3 neurons and in downstream CA1 upon reexposure to the same context. Calcium imaging of the cells reactivated in both novel and familiar contexts revealed that suppression of LC inputs at the time of encoding resulted in more variable place fields in CA3 neurons. These results suggest that neuromodulatory input from LC to CA3 is crucial for the formation of a persistent memory in the hippocampus. |
| first_indexed | 2024-09-23T09:06:10Z |
| format | Article |
| id | mit-1721.1/116867 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T09:06:10Z |
| publishDate | 2018 |
| publisher | National Academy of Sciences (U.S.) |
| record_format | dspace |
| spelling | mit-1721.1/1168672022-09-30T13:27:46Z Locus coeruleus input to hippocampal CA3 drives single-trial learning of a novel context Abe, Kuniya Wagatsuma, Akiko Okuyama, Teruhiro Sun, Chen Smith, Lillian Tonegawa, Susumu Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory RIKEN-MIT Center for Neural Circuit Genetics Wagatsuma, Akiko Okuyama, Teruhiro Sun, Chen Smith, Lillian Tonegawa, Susumu The memory for a new episode is formed immediately upon experience and can last up to a lifetime. It has been shown that the hippocampal network plays a fundamental role in the rapid acquisition of a memory of a one-time experience, in which the novelty component of the experience promotes the prompt formation of the memory. However, it remains unclear which neural circuits convey the novelty signal to the hippocampus for the single-trial learning. Here, we show that during encoding neuromodulatory input from locus coeruleus (LC) to CA3, but not CA1 or to the dentate gyrus, is necessary to facilitate novel contextual learning. Silencing LC activity during exposure to a novel context reduced subsequent reactivation of the engram cell ensembles in CA3 neurons and in downstream CA1 upon reexposure to the same context. Calcium imaging of the cells reactivated in both novel and familiar contexts revealed that suppression of LC inputs at the time of encoding resulted in more variable place fields in CA3 neurons. These results suggest that neuromodulatory input from LC to CA3 is crucial for the formation of a persistent memory in the hippocampus. 2018-07-10T15:07:19Z 2018-07-10T15:07:19Z 2017-12 2017-08 2018-07-10T14:03:34Z Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/116867 Wagatsuma, Akiko et al. “Locus Coeruleus Input to Hippocampal CA3 Drives Single-Trial Learning of a Novel Context.” Proceedings of the National Academy of Sciences 115, 2 (December 2017): E310–E316 © 2018 National Academy of Sciences https://orcid.org/0000-0003-1566-0063 https://orcid.org/0000-0002-2419-794X https://orcid.org/0000-0003-2839-8228 http://dx.doi.org/10.1073/PNAS.1714082115 Proceedings of the National Academy of Sciences Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences (U.S.) PNAS |
| spellingShingle | Abe, Kuniya Wagatsuma, Akiko Okuyama, Teruhiro Sun, Chen Smith, Lillian Tonegawa, Susumu Locus coeruleus input to hippocampal CA3 drives single-trial learning of a novel context |
| title | Locus coeruleus input to hippocampal CA3 drives single-trial learning of a novel context |
| title_full | Locus coeruleus input to hippocampal CA3 drives single-trial learning of a novel context |
| title_fullStr | Locus coeruleus input to hippocampal CA3 drives single-trial learning of a novel context |
| title_full_unstemmed | Locus coeruleus input to hippocampal CA3 drives single-trial learning of a novel context |
| title_short | Locus coeruleus input to hippocampal CA3 drives single-trial learning of a novel context |
| title_sort | locus coeruleus input to hippocampal ca3 drives single trial learning of a novel context |
| url | http://hdl.handle.net/1721.1/116867 https://orcid.org/0000-0003-1566-0063 https://orcid.org/0000-0002-2419-794X https://orcid.org/0000-0003-2839-8228 |
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