Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors
Basolateral amygdala (BLA) principal cells are capable of driving and antagonizing behaviors of opposing valence. BLA neurons project to the central amygdala (CeA), which also participates in negative and positive behaviors. However, the CeA has primarily been studied as the site for negative behavi...
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| Format: | Article |
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Elsevier BV
2018
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| Online Access: | http://hdl.handle.net/1721.1/116874 https://orcid.org/0000-0003-4455-3398 https://orcid.org/0000-0001-9658-0342 https://orcid.org/0000-0003-2839-8228 |
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| author | Kim, Joshua Zhang, Xiangyu Muralidhar, Shruti LeBlanc, Sarah Anne Tonegawa, Susumu |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Kim, Joshua Zhang, Xiangyu Muralidhar, Shruti LeBlanc, Sarah Anne Tonegawa, Susumu |
| author_sort | Kim, Joshua |
| collection | MIT |
| description | Basolateral amygdala (BLA) principal cells are capable of driving and antagonizing behaviors of opposing valence. BLA neurons project to the central amygdala (CeA), which also participates in negative and positive behaviors. However, the CeA has primarily been studied as the site for negative behaviors, and the causal role for CeA circuits underlying appetitive behaviors is poorly understood. Here, we identify several genetically distinct populations of CeA neurons that mediate appetitive behaviors and dissect the BLA-to-CeA circuit for appetitive behaviors. Protein phosphatase 1 regulatory subunit 1B⁺ BLA pyramidal neurons to dopamine receptor 1⁺ CeA neurons define a pathway for promoting appetitive behaviors, while R-spondin 2⁺ BLA pyramidal neurons to dopamine receptor 2⁺ CeA neurons define a pathway for suppressing appetitive behaviors. These data reveal genetically defined neural circuits in the amygdala that promote and suppress appetitive behaviors analogous to the direct and indirect pathways of the basal ganglia. Keywords:
central amygdala; basolateral amygdala; direct and indirect pathways; appetitive; reward; fear; amygdala circuit; feeding; drinking; freezing |
| first_indexed | 2024-09-23T14:03:26Z |
| format | Article |
| id | mit-1721.1/116874 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T14:03:26Z |
| publishDate | 2018 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1168742022-09-28T18:02:58Z Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors Kim, Joshua Zhang, Xiangyu Muralidhar, Shruti LeBlanc, Sarah Anne Tonegawa, Susumu Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Kim, Joshua Zhang, Xiangyu Muralidhar, Shruti LeBlanc, Sarah Anne Tonegawa, Susumu Basolateral amygdala (BLA) principal cells are capable of driving and antagonizing behaviors of opposing valence. BLA neurons project to the central amygdala (CeA), which also participates in negative and positive behaviors. However, the CeA has primarily been studied as the site for negative behaviors, and the causal role for CeA circuits underlying appetitive behaviors is poorly understood. Here, we identify several genetically distinct populations of CeA neurons that mediate appetitive behaviors and dissect the BLA-to-CeA circuit for appetitive behaviors. Protein phosphatase 1 regulatory subunit 1B⁺ BLA pyramidal neurons to dopamine receptor 1⁺ CeA neurons define a pathway for promoting appetitive behaviors, while R-spondin 2⁺ BLA pyramidal neurons to dopamine receptor 2⁺ CeA neurons define a pathway for suppressing appetitive behaviors. These data reveal genetically defined neural circuits in the amygdala that promote and suppress appetitive behaviors analogous to the direct and indirect pathways of the basal ganglia. Keywords: central amygdala; basolateral amygdala; direct and indirect pathways; appetitive; reward; fear; amygdala circuit; feeding; drinking; freezing National Institutes of Health (U.S.) (Grant T32GM007287) 2018-07-10T19:41:58Z 2018-07-10T19:41:58Z 2017-03 2017-01 2018-07-10T18:10:57Z Article http://purl.org/eprint/type/JournalArticle 0896-6273 1097-4199 http://hdl.handle.net/1721.1/116874 Kim, Joshua et al. “Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors.” Neuron 93, 6 (March 2017): 1464–1479 © 2017 Elsevier Inc https://orcid.org/0000-0003-4455-3398 https://orcid.org/0000-0001-9658-0342 https://orcid.org/0000-0003-2839-8228 http://dx.doi.org/10.1016/J.NEURON.2017.02.034 Neuron Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Kim, Joshua Zhang, Xiangyu Muralidhar, Shruti LeBlanc, Sarah Anne Tonegawa, Susumu Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors |
| title | Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors |
| title_full | Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors |
| title_fullStr | Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors |
| title_full_unstemmed | Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors |
| title_short | Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors |
| title_sort | basolateral to central amygdala neural circuits for appetitive behaviors |
| url | http://hdl.handle.net/1721.1/116874 https://orcid.org/0000-0003-4455-3398 https://orcid.org/0000-0001-9658-0342 https://orcid.org/0000-0003-2839-8228 |
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