Engrams and circuits crucial for systems consolidation of a memory
Episodic memories initially require rapid synaptic plasticity within the hippocampus for their formation and are gradually consolidated in neocortical networks for permanent storage. However, the engrams and circuits that support neocortical memory consolidation have thus far been unknown.We found t...
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| Format: | Article |
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American Association for the Advancement of Science (AAAS)
2018
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| Online Access: | http://hdl.handle.net/1721.1/116876 https://orcid.org/0000-0003-1982-634X https://orcid.org/0000-0002-5218-1216 https://orcid.org/0000-0003-1566-0063 https://orcid.org/0000-0003-2839-8228 |
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| author | Kitamura, Takashi Kitamura, Sachie Ogawa Roy, Dheeraj Okuyama, Teruhiro Morrissey, Mark Smith, Lillian Tonegawa, Susumu Redondo, Roger L. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Kitamura, Takashi Kitamura, Sachie Ogawa Roy, Dheeraj Okuyama, Teruhiro Morrissey, Mark Smith, Lillian Tonegawa, Susumu Redondo, Roger L. |
| author_sort | Kitamura, Takashi |
| collection | MIT |
| description | Episodic memories initially require rapid synaptic plasticity within the hippocampus for their formation and are gradually consolidated in neocortical networks for permanent storage. However, the engrams and circuits that support neocortical memory consolidation have thus far been unknown.We found that neocortical prefrontal memory engram cells, which are critical for remote contextual fear memory, were rapidly generated during initial learning through inputs from both the hippocampal-entorhinal cortex network and the basolateral amygdala. After their generation, the prefrontal engram cells, with support from hippocampal memory engram cells, became functionally mature with time. Whereas hippocampal engram cells gradually became silent with time, engram cells in the basolateral amygdala, which were necessary for fear memory, were maintained. Our data provide new insights into the functional reorganization of engrams and circuits underlying systems consolidation of memory. |
| first_indexed | 2024-09-23T16:55:09Z |
| format | Article |
| id | mit-1721.1/116876 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T16:55:09Z |
| publishDate | 2018 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/1168762022-10-03T09:10:38Z Engrams and circuits crucial for systems consolidation of a memory Kitamura, Takashi Kitamura, Sachie Ogawa Roy, Dheeraj Okuyama, Teruhiro Morrissey, Mark Smith, Lillian Tonegawa, Susumu Redondo, Roger L. Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Kitamura, Takashi Kitamura, Sachie Ogawa Roy, Dheeraj Okuyama, Teruhiro Morrissey, Mark Smith, Lillian Redondo Pena, Roger L Tonegawa, Susumu Episodic memories initially require rapid synaptic plasticity within the hippocampus for their formation and are gradually consolidated in neocortical networks for permanent storage. However, the engrams and circuits that support neocortical memory consolidation have thus far been unknown.We found that neocortical prefrontal memory engram cells, which are critical for remote contextual fear memory, were rapidly generated during initial learning through inputs from both the hippocampal-entorhinal cortex network and the basolateral amygdala. After their generation, the prefrontal engram cells, with support from hippocampal memory engram cells, became functionally mature with time. Whereas hippocampal engram cells gradually became silent with time, engram cells in the basolateral amygdala, which were necessary for fear memory, were maintained. Our data provide new insights into the functional reorganization of engrams and circuits underlying systems consolidation of memory. 2018-07-10T19:56:18Z 2018-07-10T19:56:18Z 2017-04 2016-12 2018-07-10T18:01:56Z Article http://purl.org/eprint/type/JournalArticle 0036-8075 1095-9203 http://hdl.handle.net/1721.1/116876 Kitamura, Takashi et al. “Engrams and Circuits Crucial for Systems Consolidation of a Memory.” Science 356, 6333 (April 2017): 73–78 © 2016 American Association for the Advancement of Science https://orcid.org/0000-0003-1982-634X https://orcid.org/0000-0002-5218-1216 https://orcid.org/0000-0003-1566-0063 https://orcid.org/0000-0003-2839-8228 http://dx.doi.org/10.1126/SCIENCE.AAM6808 Science Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Association for the Advancement of Science (AAAS) PMC |
| spellingShingle | Kitamura, Takashi Kitamura, Sachie Ogawa Roy, Dheeraj Okuyama, Teruhiro Morrissey, Mark Smith, Lillian Tonegawa, Susumu Redondo, Roger L. Engrams and circuits crucial for systems consolidation of a memory |
| title | Engrams and circuits crucial for systems consolidation of a memory |
| title_full | Engrams and circuits crucial for systems consolidation of a memory |
| title_fullStr | Engrams and circuits crucial for systems consolidation of a memory |
| title_full_unstemmed | Engrams and circuits crucial for systems consolidation of a memory |
| title_short | Engrams and circuits crucial for systems consolidation of a memory |
| title_sort | engrams and circuits crucial for systems consolidation of a memory |
| url | http://hdl.handle.net/1721.1/116876 https://orcid.org/0000-0003-1982-634X https://orcid.org/0000-0002-5218-1216 https://orcid.org/0000-0003-1566-0063 https://orcid.org/0000-0003-2839-8228 |
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