Mouth development
WIREs Developmental Biology published by Wiley Periodicals, Inc. A mouth is present in all animals, and comprises an opening from the outside into the oral cavity and the beginnings of the digestive tract to allow eating. This review focuses on the earliest steps in mouth formation. In the first hal...
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| Format: | Article |
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Wiley-Blackwell
2018
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| Online Access: | http://hdl.handle.net/1721.1/116900 https://orcid.org/0000-0002-2634-6689 https://orcid.org/0000-0002-4890-424X |
| _version_ | 1811088767020171264 |
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| author | Jacox, Laura A. Saldanha, Francesca Chen, Justin Sive, Hazel L. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Jacox, Laura A. Saldanha, Francesca Chen, Justin Sive, Hazel L. |
| author_sort | Jacox, Laura A. |
| collection | MIT |
| description | WIREs Developmental Biology published by Wiley Periodicals, Inc. A mouth is present in all animals, and comprises an opening from the outside into the oral cavity and the beginnings of the digestive tract to allow eating. This review focuses on the earliest steps in mouth formation. In the first half, we conclude that the mouth arose once during evolution. In all animals, the mouth forms from ectoderm and endoderm. A direct association of oral ectoderm and digestive endoderm is present even in triploblastic animals, and in chordates, this region is known as the extreme anterior domain (EAD). Further support for a single origin of the mouth is a conserved set of genes that form a ‘mouth gene program’ including foxA and otx2. In the second half of this review, we discuss steps involved in vertebrate mouth formation, using the frog Xenopus as a model. The vertebrate mouth derives from oral ectoderm from the anterior neural ridge, pharyngeal endoderm and cranial neural crest (NC). Vertebrates form a mouth by breaking through the body covering in a precise sequence including specification of EAD ectoderm and endoderm as well as NC, formation of a ‘pre-mouth array,’ basement membrane dissolution, stomodeum formation, and buccopharyngeal membrane perforation. In Xenopus, the EAD is also a craniofacial organizer that guides NC, while reciprocally, the NC signals to the EAD to elicit its morphogenesis into a pre-mouth array. Human mouth anomalies are prevalent and are affected by genetic and environmental factors, with understanding guided in part by use of animal models. |
| first_indexed | 2024-09-23T14:07:13Z |
| format | Article |
| id | mit-1721.1/116900 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T14:07:13Z |
| publishDate | 2018 |
| publisher | Wiley-Blackwell |
| record_format | dspace |
| spelling | mit-1721.1/1169002022-10-01T19:19:21Z Mouth development Jacox, Laura A. Saldanha, Francesca Chen, Justin Sive, Hazel L. Massachusetts Institute of Technology. Department of Biology Chen, Justin Sive, Hazel L WIREs Developmental Biology published by Wiley Periodicals, Inc. A mouth is present in all animals, and comprises an opening from the outside into the oral cavity and the beginnings of the digestive tract to allow eating. This review focuses on the earliest steps in mouth formation. In the first half, we conclude that the mouth arose once during evolution. In all animals, the mouth forms from ectoderm and endoderm. A direct association of oral ectoderm and digestive endoderm is present even in triploblastic animals, and in chordates, this region is known as the extreme anterior domain (EAD). Further support for a single origin of the mouth is a conserved set of genes that form a ‘mouth gene program’ including foxA and otx2. In the second half of this review, we discuss steps involved in vertebrate mouth formation, using the frog Xenopus as a model. The vertebrate mouth derives from oral ectoderm from the anterior neural ridge, pharyngeal endoderm and cranial neural crest (NC). Vertebrates form a mouth by breaking through the body covering in a precise sequence including specification of EAD ectoderm and endoderm as well as NC, formation of a ‘pre-mouth array,’ basement membrane dissolution, stomodeum formation, and buccopharyngeal membrane perforation. In Xenopus, the EAD is also a craniofacial organizer that guides NC, while reciprocally, the NC signals to the EAD to elicit its morphogenesis into a pre-mouth array. Human mouth anomalies are prevalent and are affected by genetic and environmental factors, with understanding guided in part by use of animal models. National Institute of Dental and Craniofacial Research (U.S.) (Grant RO1 DE021109) 2018-07-11T16:13:05Z 2018-07-11T16:13:05Z 2017-08 2017-03 2018-07-10T12:16:30Z Article http://purl.org/eprint/type/JournalArticle 1759-7684 http://hdl.handle.net/1721.1/116900 Chen, Justin et al. “Mouth Development.” Wiley Interdisciplinary Reviews: Developmental Biology 6, 5 (May 2017): e275 © 2017 The Authors https://orcid.org/0000-0002-2634-6689 https://orcid.org/0000-0002-4890-424X http://dx.doi.org/10.1002/WDEV.275 Wiley Interdisciplinary Reviews: Developmental Biology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Wiley-Blackwell Wiley |
| spellingShingle | Jacox, Laura A. Saldanha, Francesca Chen, Justin Sive, Hazel L. Mouth development |
| title | Mouth development |
| title_full | Mouth development |
| title_fullStr | Mouth development |
| title_full_unstemmed | Mouth development |
| title_short | Mouth development |
| title_sort | mouth development |
| url | http://hdl.handle.net/1721.1/116900 https://orcid.org/0000-0002-2634-6689 https://orcid.org/0000-0002-4890-424X |
| work_keys_str_mv | AT jacoxlauraa mouthdevelopment AT saldanhafrancesca mouthdevelopment AT chenjustin mouthdevelopment AT sivehazell mouthdevelopment |