Biochemical Underpinnings of Immune Cell Metabolic Phenotypes
The metabolism of immune cells affects their function and influences host immunity. This review explores how immune cell metabolic phenotypes reflect biochemical dependencies and highlights evidence that both the metabolic state of immune cells and nutrient availability can alter immune responses. T...
| Main Authors: | , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Published: |
Elsevier BV
2018
|
| Online Access: | http://hdl.handle.net/1721.1/116915 https://orcid.org/0000-0002-6702-4192 |
| _version_ | 1826191026625183744 |
|---|---|
| author | Olenchock, Benjamin A. Rathmell, Jeffrey C. Vander Heiden, Matthew G. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Olenchock, Benjamin A. Rathmell, Jeffrey C. Vander Heiden, Matthew G. |
| author_sort | Olenchock, Benjamin A. |
| collection | MIT |
| description | The metabolism of immune cells affects their function and influences host immunity. This review explores how immune cell metabolic phenotypes reflect biochemical dependencies and highlights evidence that both the metabolic state of immune cells and nutrient availability can alter immune responses. The central importance of oxygen, energetics, and redox homeostasis in immune cell metabolism, and how these factors are reflected in different metabolic phenotypes, is also discussed. Linking immune cell metabolic phenotype to effector functions is important to understand how altering metabolism can impact the way in which immune cells meet their metabolic demands and affect the immune response in various disease contexts. |
| first_indexed | 2024-09-23T08:48:58Z |
| format | Article |
| id | mit-1721.1/116915 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T08:48:58Z |
| publishDate | 2018 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1169152022-09-30T11:28:56Z Biochemical Underpinnings of Immune Cell Metabolic Phenotypes Olenchock, Benjamin A. Rathmell, Jeffrey C. Vander Heiden, Matthew G. Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Vander Heiden, Matthew G. The metabolism of immune cells affects their function and influences host immunity. This review explores how immune cell metabolic phenotypes reflect biochemical dependencies and highlights evidence that both the metabolic state of immune cells and nutrient availability can alter immune responses. The central importance of oxygen, energetics, and redox homeostasis in immune cell metabolism, and how these factors are reflected in different metabolic phenotypes, is also discussed. Linking immune cell metabolic phenotype to effector functions is important to understand how altering metabolism can impact the way in which immune cells meet their metabolic demands and affect the immune response in various disease contexts. National Institutes of Health (U.S.) (Grant R01CA168653) National Institutes of Health (U.S.) (Grant R01CA201276) 2018-07-11T19:03:11Z 2018-07-11T19:03:11Z 2017-05 2018-07-11T17:37:54Z Article http://purl.org/eprint/type/JournalArticle 1074-7613 1097-4180 http://hdl.handle.net/1721.1/116915 Olenchock, Benjamin A. et al. “Biochemical Underpinnings of Immune Cell Metabolic Phenotypes.” Immunity 46, 5 (May 2017): 703–713 © 2017 Elsevier Inc https://orcid.org/0000-0002-6702-4192 http://dx.doi.org/10.1016/J.IMMUNI.2017.04.013 Immunity Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Olenchock, Benjamin A. Rathmell, Jeffrey C. Vander Heiden, Matthew G. Biochemical Underpinnings of Immune Cell Metabolic Phenotypes |
| title | Biochemical Underpinnings of Immune Cell Metabolic Phenotypes |
| title_full | Biochemical Underpinnings of Immune Cell Metabolic Phenotypes |
| title_fullStr | Biochemical Underpinnings of Immune Cell Metabolic Phenotypes |
| title_full_unstemmed | Biochemical Underpinnings of Immune Cell Metabolic Phenotypes |
| title_short | Biochemical Underpinnings of Immune Cell Metabolic Phenotypes |
| title_sort | biochemical underpinnings of immune cell metabolic phenotypes |
| url | http://hdl.handle.net/1721.1/116915 https://orcid.org/0000-0002-6702-4192 |
| work_keys_str_mv | AT olenchockbenjamina biochemicalunderpinningsofimmunecellmetabolicphenotypes AT rathmelljeffreyc biochemicalunderpinningsofimmunecellmetabolicphenotypes AT vanderheidenmatthewg biochemicalunderpinningsofimmunecellmetabolicphenotypes |