Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

Mammalian tissues rely on a variety of nutrients to support their physiological functions. It is known that altered metabolism is involved in the pathogenesis of cancer, but which nutrients support the inappropriate growth of intact malignant tumors is incompletely understood. Amino acids are essent...

Full description

Bibliographic Details
Main Authors:	Kellersberger, Katherine A, Stall, Brian K, Stephanopoulos, Gregory, Bar-Sagi, Dafna, Han, Jongyoon, Rabinowitz, Joshua D, Davidson, Shawn M, Jonas, Oliver H., Keibler, Mark Andrew, Hou, Han Wei, Luengo, Alba, Mayers, Jared R., Wyckoff, Jeffrey, Del Rosario, Amanda M, Whitman, Matthew A, Condon, Kendall Janine, Lammers, Alex A, Langer, Robert S, Vander Heiden, Matthew G., Cima, Michael J.
Other Authors:	Massachusetts Institute of Technology. Department of Biology
Format:	Article
Published:	Nature Publishing Group 2018
Online Access:	http://hdl.handle.net/1721.1/116946 https://orcid.org/0000-0003-2512-2007 https://orcid.org/0000-0002-5410-6543 https://orcid.org/0000-0002-4236-0229 https://orcid.org/0000-0002-8607-1787 https://orcid.org/0000-0002-9515-8892 https://orcid.org/0000-0003-2379-6139 https://orcid.org/0000-0003-4255-0492 https://orcid.org/0000-0002-6702-4192

Similar Items

Dexamethasone: chondroprotective corticosteroid or catabolic killer?
by: Black, Robert Xavier, et al.
Published: (2020)

Histidine catabolism is a major determinant of methotrexate sensitivity
by: Kanarek, Naama, et al.
Published: (2020)

Investigating effects of polyamine catabolism on epidermal differentiation
by: Ling, Blysse
Published: (2019)

Dynamic regulation of pectin catabolism in the pathogenicity of Dickeya dadantii
by: Debra Ruth David
Published: (2012)

Examining metabolic vulnerabilities for cancer therapy
by: Luengo, Alba
Published: (2018)

Catabolic activity and biofilm formation of foodborne Listeria monocytogenes strains
by: Sharar, Nowshin Shyara, et al.
Published: (2018)

Variable carbon catabolism among salmonella enterica serovar typhi isolates
by: Chai, L.C., et al.
Published: (2012)

Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy
by: Luengo, Alba, et al.
Published: (2014)

A systematic approach for cataloging mTORC1 regulators
by: Condon, Kendall J.
Published: (2022)

Anti-catabolic effect of fibroblast growth factor-2 in human articular cartilage
by: Sawaji, Y, et al.
Published: (2009)

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition
by: Luengo, Alba, et al.
Published: (2022)

Increased energy demand from anabolic-catabolic processes drives β-lactam antibiotic lethality
by: Lobritz, Michael A, et al.
Published: (2023)

Moderate dynamic compression inhibits pro-catabolic response of cartilage to mechanical injury, TNF-α and IL-6, but accentuates degradation above a strain threshold
by: Li, Yang, et al.
Published: (2015)

Low oxygen tension increased fibronectin fragment induced catabolic activities - response prevented with biomechanical signals
by: Parker, E., et al.
Published: (2013)

Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism
by: Rando, Gianpaolo, et al.
Published: (2016)

Tissue catabolism and donor-specific dexamethasone response in a human osteochondral model of post-traumatic osteoarthritis
by: Black, Rebecca M., et al.
Published: (2022)

Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs
by: Sabatini, David M.
Published: (2020)

In vitro model of injury/cytokine-induced cartilage catabolism modulated by dynamic compression, growth factors, and glucocorticoids
by: Li, Yang, Ph. D. Massachusetts Institute of Technology
Published: (2013)

Transfer of a Catabolic Pathway for Chloromethane in Methylobacterium Strains Highlights Different Limitations for Growth with Chloromethane or with Dichloromethane
by: Vuilleumier, Stéphane, et al.
Published: (2017)

Antibiotic resistance and enhanced insecticide catabolism as consequences of steroid induction in the gram-negative bacterium Comamonas testosteroni.
by: Oppermann, U, et al.
Published: (1996)

Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting
by: Alkan, H. Furkan, et al.
Published: (2020)

REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks
by: Chatterjee, Nimrat, et al.
Published: (2021)

Expanding the concepts and tools of metabolic engineering to elucidate cancer metabolism
by: Fendt, Sarah-Maria, et al.
Published: (2014)

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
by: Commisso, Cosimo, et al.
Published: (2014)

Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-L-proline by a microbial glycyl radical enzyme
by: Backman, Lindsey R., et al.
Published: (2020)

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
by: Fendt, Sarah-Maria, et al.
Published: (2014)

If It’s Not One Thing, It’s Another: An Inverse Relationship of Malignancy and Atherosclerotic Disease
by: Li, Matthew, et al.
Published: (2015)

Metabolic requirements for cancer cell proliferation
by: Iliopoulos, Othon, et al.
Published: (2018)

Famine versus feast: understanding the metabolism of tumors in vivo
by: Vander Heiden, Matthew G., et al.
Published: (2016)

Characterization of cardiac lead perforation risk via a dynamic simulated environment
by: Rosario, Matthew J
Published: (2012)

Finite element based micromechanical modeling of periodic composite microstructures
by: Rosario, Matthew J
Published: (2010)

Charge based intra-cartilage delivery of single dose dexamethasone using Avidin nano-carriers suppresses cytokine-induced catabolism long term
by: Bajpayee, Ambika Goel, et al.
Published: (2017)

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein
by: Kamphorst, J. J., et al.
Published: (2016)

Combined effect of plant-based protein supplementation with resistance training on muscular strength, protein catabolism, immune functions and bone metabolism markers in adult males
by: Ahmad, Azaizirawati
Published: (2018)

Effects of gamma oryzanol supplimentation of lipid profile, anabolic/ catabolic hormones, circulating binding proteins and anthropometric changes in young males during resistance training
by: Eslami, Saghar
Published: (2012)

Effects of gamma oryzanol supplementation of lipid profile, anabolic/catabolic hormones, circulating binding proteins and anthropometric changes in young males during resistance training
by: Eslami, Saghar
Published: (2012)

Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer
by: Luengo, Alba, et al.
Published: (2020)

Developing a Generic Design Pattern for a Learning Object to Support Student Reflection
by: Hardbattle, Dafna, et al.
Published: (2011)

Does Reflective Writing in the PDP Improve Science and Engineering Students’ Learning?
by: Chalk, Peter, et al.
Published: (2007)

Electrochemical modulation enhances the selectivity of peripheral neurostimulation in vivo
by: Flavin, Matthew T, et al.
Published: (2022)