Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction

Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction

Diabetic nephropathy (DN) is a major cause of end-stage renal disease, and therapeutic options for preventing its progression are limited. To identify novel therapeutic strategies, we studied protective factors for DN using proteomics on glomeruli from individuals with extreme duration of diabetes (...

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Bibliographic Details
Main Authors: Qi, Weier, Keenan, Hillary A, Li, Qian, Ishikado, Atsushi, Kannt, Aimo, Sadowski, Thorsten, Yorek, Mark A, Wu, I-Hsien, Lockhart, Samuel, Coppey, Lawrence J, Pfenninger, Anja, Liew, Chong Wee, Qiang, Guifen, Burkart, Alison M, Hastings, Stephanie, Pober, David, Cahill, Christopher, Niewczas, Monika A, Israelsen, William J, Tinsley, Liane, Stillman, Isaac E, Amenta, Peter S, Feener, Edward P, Stanton, Robert C, King, George L, Vander Heiden, Matthew G.
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Published: Nature Publishing Group 2018
Online Access:http://hdl.handle.net/1721.1/116949
https://orcid.org/0000-0002-6702-4192

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