Mechanisms of DNA damage, repair, and mutagenesis
Living organisms are continuously exposed to a myriad of DNA damaging agents that can impact health and modulate disease-states. However, robust DNA repair and damage-bypass mechanisms faithfully protect the DNA by either removing or tolerating the damage to ensure an overall survival. Deviations in...
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| Format: | Article |
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Wiley Blackwell
2018
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| Online Access: | http://hdl.handle.net/1721.1/116957 https://orcid.org/0000-0001-7243-8261 |
| _version_ | 1826208596780646400 |
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| author | Chatterjee, Nimrat Walker, Graham C. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Chatterjee, Nimrat Walker, Graham C. |
| author_sort | Chatterjee, Nimrat |
| collection | MIT |
| description | Living organisms are continuously exposed to a myriad of DNA damaging agents that can impact health and modulate disease-states. However, robust DNA repair and damage-bypass mechanisms faithfully protect the DNA by either removing or tolerating the damage to ensure an overall survival. Deviations in this fine-tuning are known to destabilize cellular metabolic homeostasis, as exemplified in diverse cancers where disruption or deregulation of DNA repair pathways results in genome instability. Because routinely used biological, physical and chemical agents impact human health, testing their genotoxicity and regulating their use have become important. In this introductory review, we will delineate mechanisms of DNA damage and the counteracting repair/tolerance pathways to provide insights into the molecular basis of genotoxicity in cells that lays the foundation for subsequent articles in this issue. Environ. Mol. Mutagen. 58:235–263, 2017 © 2017 Wiley Periodicals, Inc. |
| first_indexed | 2024-09-23T14:07:49Z |
| format | Article |
| id | mit-1721.1/116957 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T14:07:49Z |
| publishDate | 2018 |
| publisher | Wiley Blackwell |
| record_format | dspace |
| spelling | mit-1721.1/1169572022-09-28T18:45:46Z Mechanisms of DNA damage, repair, and mutagenesis Chatterjee, Nimrat Walker, Graham C. Massachusetts Institute of Technology. Department of Biology Chatterjee, Nimrat Walker, Graham C Living organisms are continuously exposed to a myriad of DNA damaging agents that can impact health and modulate disease-states. However, robust DNA repair and damage-bypass mechanisms faithfully protect the DNA by either removing or tolerating the damage to ensure an overall survival. Deviations in this fine-tuning are known to destabilize cellular metabolic homeostasis, as exemplified in diverse cancers where disruption or deregulation of DNA repair pathways results in genome instability. Because routinely used biological, physical and chemical agents impact human health, testing their genotoxicity and regulating their use have become important. In this introductory review, we will delineate mechanisms of DNA damage and the counteracting repair/tolerance pathways to provide insights into the molecular basis of genotoxicity in cells that lays the foundation for subsequent articles in this issue. Environ. Mol. Mutagen. 58:235–263, 2017 © 2017 Wiley Periodicals, Inc. National Institute of Environmental Health Sciences (Grant ES-015818) 2018-07-12T19:46:59Z 2018-07-12T19:46:59Z 2017-05 2016-09 2018-07-12T13:29:25Z Article http://purl.org/eprint/type/JournalArticle 0893-6692 1098-2280 http://hdl.handle.net/1721.1/116957 Chatterjee, Nimrat, and Graham C. Walker. “Mechanisms of DNA Damage, Repair, and Mutagenesis.” Environmental and Molecular Mutagenesis 58, 5 (May 2017): 235–263 © 2017 Wiley Periodicals, Inc https://orcid.org/0000-0001-7243-8261 http://dx.doi.org/10.1002/EM.22087 Environmental and Molecular Mutagenesis Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley Blackwell PMC |
| spellingShingle | Chatterjee, Nimrat Walker, Graham C. Mechanisms of DNA damage, repair, and mutagenesis |
| title | Mechanisms of DNA damage, repair, and mutagenesis |
| title_full | Mechanisms of DNA damage, repair, and mutagenesis |
| title_fullStr | Mechanisms of DNA damage, repair, and mutagenesis |
| title_full_unstemmed | Mechanisms of DNA damage, repair, and mutagenesis |
| title_short | Mechanisms of DNA damage, repair, and mutagenesis |
| title_sort | mechanisms of dna damage repair and mutagenesis |
| url | http://hdl.handle.net/1721.1/116957 https://orcid.org/0000-0001-7243-8261 |
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