The SUMO guards for SNAIL
The cell-biological program termed epithelial-mesenchymal transition (EMT) plays a key role in adenocarcinoma progression, invasion, and metastasis. An EMT operating within carcinoma cells can be activated by a variety of paracrine signals arising in the tumor microenvironment. These EMT-inducing si...
| Main Authors: | , |
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| Format: | Article |
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Impact Journals, LLC
2018
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| Online Access: | http://hdl.handle.net/1721.1/116966 https://orcid.org/0000-0002-0895-3557 |
| Summary: | The cell-biological program termed epithelial-mesenchymal transition (EMT) plays a key role in adenocarcinoma progression, invasion, and metastasis. An EMT operating within carcinoma cells can be activated by a variety of paracrine signals arising in the tumor microenvironment. These EMT-inducing signals trigger profound transcription changes through activation of EMT-inducing transcription factors (EMT-TFs), leading to repression of genes associated with the epithelial differentiation program and activation of those associated with the mesenchymal program. |
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