Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells?
Cancer stem cells (CSCs) are similar to normal stem cells in their ability to self-renew and to generate large populations of more differentiated descendants. In contrast to the hierarchical organization that is presumed to be the prevalent mode of normal tissue homeostasis, phenotypic plasticity al...
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| Format: | Article |
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Wiley Blackwell
2018
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| Online Access: | http://hdl.handle.net/1721.1/116967 https://orcid.org/0000-0002-0895-3557 |
| _version_ | 1811075168631521280 |
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| author | Scheel, Christina Weinberg, Robert A |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Scheel, Christina Weinberg, Robert A |
| author_sort | Scheel, Christina |
| collection | MIT |
| description | Cancer stem cells (CSCs) are similar to normal stem cells in their ability to self-renew and to generate large populations of more differentiated descendants. In contrast to the hierarchical organization that is presumed to be the prevalent mode of normal tissue homeostasis, phenotypic plasticity allows cancer cells to dynamically enter into and exit from stem-cell states. The epithelial-mesenchymal transition (EMT) has been closely associated with the acquisition of both invasive and stem-cell properties in cancer cells. Thereby, EMT programs emerge as important regulators of phenotypic plasticity in cancer cells including their entrance into stem-cell states. Much is still to be learned about the regulation of EMTs through epigenetic mechanisms in cancer cells and the contributions that EMT programs make to normal tissue homeostasis. |
| first_indexed | 2024-09-23T10:01:55Z |
| format | Article |
| id | mit-1721.1/116967 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T10:01:55Z |
| publishDate | 2018 |
| publisher | Wiley Blackwell |
| record_format | dspace |
| spelling | mit-1721.1/1169672022-09-26T15:19:08Z Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? Scheel, Christina Weinberg, Robert A Massachusetts Institute of Technology. Department of Biology Ludwig Center for Molecular Oncology (Massachusetts Institute of Technology) Weinberg, Robert A Cancer stem cells (CSCs) are similar to normal stem cells in their ability to self-renew and to generate large populations of more differentiated descendants. In contrast to the hierarchical organization that is presumed to be the prevalent mode of normal tissue homeostasis, phenotypic plasticity allows cancer cells to dynamically enter into and exit from stem-cell states. The epithelial-mesenchymal transition (EMT) has been closely associated with the acquisition of both invasive and stem-cell properties in cancer cells. Thereby, EMT programs emerge as important regulators of phenotypic plasticity in cancer cells including their entrance into stem-cell states. Much is still to be learned about the regulation of EMTs through epigenetic mechanisms in cancer cells and the contributions that EMT programs make to normal tissue homeostasis. National Institutes of Health (U.S.) (Grant CA12515) National Cancer Institute (U.S.) (Grant CA12515) National Institutes of Health (U.S.) (Grant DE020817) National Cancer Institute (U.S.) (Grant DE020817) 2018-07-13T13:20:43Z 2018-07-13T13:20:43Z 2011-07 2010-12 2018-07-12T17:43:25Z Article http://purl.org/eprint/type/JournalArticle 0020-7136 1097-0215 http://hdl.handle.net/1721.1/116967 Scheel, Christina, and Robert A. Weinberg. “Phenotypic Plasticity and Epithelial-Mesenchymal Transitions in Cancer and Normal Stem Cells?” International Journal of Cancer 129, no. 10 (August 29, 2011): 2310–2314 © 2011 UICC https://orcid.org/0000-0002-0895-3557 http://dx.doi.org/10.1002/ijc.26311 International Journal of Cancer Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley Blackwell PMC |
| spellingShingle | Scheel, Christina Weinberg, Robert A Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? |
| title | Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? |
| title_full | Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? |
| title_fullStr | Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? |
| title_full_unstemmed | Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? |
| title_short | Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? |
| title_sort | phenotypic plasticity and epithelial mesenchymal transitions in cancer and normal stem cells |
| url | http://hdl.handle.net/1721.1/116967 https://orcid.org/0000-0002-0895-3557 |
| work_keys_str_mv | AT scheelchristina phenotypicplasticityandepithelialmesenchymaltransitionsincancerandnormalstemcells AT weinbergroberta phenotypicplasticityandepithelialmesenchymaltransitionsincancerandnormalstemcells |